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EC number: 236-828-6 | CAS number: 13501-76-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EC10/LC10 or NOEC for aquatic micro-organisms: 1000 mg/L
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
There are no microorganism toxicity data available for (3 chloropropyl)diethoxymethylsilane, therefore, good quality data for the structurally-related substance, (chloromethyl)triethoxysilane (CAS 015267-95-5), have been read across. Both substances hydrolyse to structurally-related silanol hydrolysis products. It is therefore considered valid to read-across the results for (chloromethyl)triethoxysilane (CAS 015267-95-5) to fill the data gap for the registered substance.Additional information is given in a supporting report (PFA, 2013m) attached in Section 13 of the IUCLID 5 dossier.
Both (3 chloropropyl)diethoxymethylsilane and (chloromethyl)triethoxysilane are within an analogue group of substances that exhibit no evidence of significant toxicity to microorganisms.
It is therefore considered valid to read-across the results for(chloromethyl)triethoxysilaneto fill the data gap for the registered substance.
Table 7.4.1 presents microorganism toxicity data available for substances within the analogue group (III-15) of chlorosilanes, siloxanes, silanes and alkoxysilanes etc, with chloroalkyl functional group(s) in side chain after any very rapid hydrolysis has been accounted for.
Table7.4.2 Microorganism toxicity data available for substances within the relevant sub-class (III-15) of chemicals
CAS |
Name |
Result: E(I)C50 (mg/l) |
Result: NOEC (or EC10/ EC20) (mg/l) |
Guideline Number |
Test method |
Species |
Duration |
Reliability |
007787-93-1 |
Dichloro(3-chloropropyl)methylsilane |
400 |
|
88/302/EC |
ASRI |
|
3hr |
1a |
002530-87-2 |
3-chloropropyltrimethoxysilane |
|
EC10 1.1 ml/l |
Hüls method |
oxygen consumption |
P. putida |
5 hr |
2c |
005089-70-3 |
(3-chloropropyl)triethoxysilane |
|
EC10 >2 ml/l |
Hüls method |
oxygen consumption |
P putida |
5 hr |
2c |
015267-95-5 |
(chloromethyl)triethoxysilane |
>1000 |
≥1000 mg/l |
OECD 209 |
ASRI |
|
3 hr |
1a |
An EC50of >1000 mg/l and a NOEC of 1000 mg/l for toxicity to microorganisms were determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test, NOTOX, 2011). Additional information are available for (3-chloropropyl)triethoxysilane (CAS 5089-70-3) as supporting information to (3-chloropropyl)diethoxymethylsilane (CAS 13501-76-3) because they are structurally-related substances and they have similar hydrolysis half-lives. A 5 h EC10value of 2000 µl/l was determined for toxicity to microorganisms (Pseudomonas putida).
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