Registration Dossier
Registration Dossier
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EC number: 601-672-3 | CAS number: 120118-14-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: other: base-pair substitutions and frameshift mutations
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
- EC Number:
- 601-672-3
- Cas Number:
- 120118-14-1
- Molecular formula:
- C11H8ClN3
- IUPAC Name:
- 5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA 1535, TA 100, TA 1537, TA 98, TA 102
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- INCORPORATION TEST:
up to 5000 ug/plate
PREINCUBATION TEST:
up to 160 ug/tube
Controlsopen allclose all
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- sodium azide
- Remarks:
- only used without S9 mix
Migrated to IUCLID6: and nitrofurantoin, 4-nitro-1,2-phenylene diamine, cumene hydroperoxide
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminoanthracene
- Remarks:
- only used with S9 mix
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
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