Registration Dossier
Registration Dossier
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EC number: 601-672-3 | CAS number: 120118-14-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
- EC Number:
- 601-672-3
- Cas Number:
- 120118-14-1
- Molecular formula:
- C11H8ClN3
- IUPAC Name:
- 5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: single application into the conjunctival sac of the right eye the left eye served as a control
- Observation period (in vivo):
- Examinations: prior to administration and 1 h, 24 h, 48 h and 72 h after administration
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Remarks:
- and animal #2
- Time point:
- other: 24 h
- Max. score:
- 1
- Reversibility:
- fully reversible
- Remarks:
- after 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 48 h
- Max. score:
- 1
- Reversibility:
- fully reversible
- Remarks:
- after 72 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Remarks:
- and animal #3
- Time point:
- other: 24 and 48 h
- Max. score:
- 1
- Reversibility:
- fully reversible
- Remarks:
- after 72 h
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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