1,1,1"((methylsilanetriyl)tris)(oxy))tris(2-methylpropan-2-amine)

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

GLP compliance:

no

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

2.028

Temp.:

25 °C

pH:

7.9

Remarks on result:

other: Deviation=±0.010

The Partition coefficient (log P_ow) of the 1,1',1"-((methylsilanetriyl)tris(oxy))tris(2-methylpropan-2-amine) (CAS No. 28911-48-0) was found to be 2.028±0.010 at 25°C.

 

Table 1:

Reference substances	tR1	tR2	Mean tR± SD	k	log k	Log Pow
Formamide	0.997	1.000	0.999±0.002	NA	NA	NA
4-Acetylpyridine	1.142	1.143	1.143±0.001	0.144	-0.841	0.6
Cinnamyl alcohol	1.486	1.485	1.486±0.001	0.488	-0.312	1.7
Nitrobenzene	1.631	1.628	1.630±0.002	0.632	-0.199	2.0
Allyl phenyl ether	2.735	2.732	2.734±0.002	1.738	0.240	3.0
Ethylbenzene	3.738	3.753	3.746±0.011	2.751	0.440	3.5
Biphenyl	4.976	4.981	4.979±0.004	3.986	0.601	3.6

able 1- The above table indicates, six generalized reference subsatnces were taken to prepare the calibration graph. Individual reference substances were allowed to pass through the column on fixed operating conditions in order to obtain the values of t_Rand SD.  These values are then used to determine k which is then converted to log k value. (applying equation no. 1). This log k was then plotted on the calibration curve to determined log P_owvalue of each.

Test chemical		k	Log k	Log Pow	Mean of Log Pow± S.D
tR1	1.666	0.669	-0.175	2.035	2.028±0.010
tR2	1.656	0.658	-0.181	2.021

Conclusions:

The Log Powvalue of test substance was determined to be to be 2.028±0.010 at 25°C.

Executive summary:

The partition coefficient (n-octanol/water) of test substance was determined as per the HPLC method (OECD Guideline-117). The Log P_owvalue was found to be 2.028±0.010 at 25°,.the substance is hydrophillic in nature

Description of key information

The Log P_owvalue of test substance was estimated to be 2.028±0.010 at 25°C.

Key value for chemical safety assessment

Log Kow (Log Pow):

2.028

at the temperature of:

25 °C

Additional information

The partition coefficient (n-octanol/water) of test substance was determined as per the HPLC method (OECD Guideline-117). The Log P_owvalue was found to be 2.028±0.010 at 25°C..the substance is hydrophillic in nature