Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Hydrolysis
On the basis of the experimental studies of the read across chemical and applying the weight of evidence approach and by evaluating the results, the hydrolysis half-life value of test chemical can be expected as >1 yr at 25°C/50°C and pH of 4, 7 and 9, respectively. Thus, test chemical was considered to be hydrolytically stable.
Additional information
Hydrolysis
Data available of the read across chemicals has been reviewed to determine the hydrolysis half-life value of test chemical. The studies are as mentioned below:
Hydrolysis study was carried out for determining the half-life value of test chemical. The study was performed in accordance with the OECD Guideline 111 (Hydrolysis as a Function of pH). The test substance was dissolved in buffer at pH 4, 7 and 9 and maintained at 50°C for a total of 125 hr in a preliminary test. The incubated vessels were sampled at approximately 5.5, 22.8, 28.7, 95.1, 100.8, 119.4 and 125 hours after starting the incubation. The samples taken from the vessels were assays for test material using capillary electrophoresis. If the test material demonstrated hydrolysis in a certain range, further test would be conducted to better define the kinetics of the reaction. After incubation at pH 4, 7 or 9 for up to 125 hours the concentration of test material was similar with the starting concentration. Concentration of the test material did not decrease with time and was as follows at the beginning and end of the incubation period. A secondary test was not required according to the OECD 111 criteria. The hydrochloride salt and the free base are identical in buffered solution. No degradation products were formed. Hydrolysis half-life value of test chemical was determined to be >1 yr at 50°C and pH of 4, 7 and 9, respectively. Thus, test chemical was considered to be hydrolytically stable.
Another hydrolysis study was carried out for determining the half-life value of test chemical. The hallf-life value of test chemical was determined to be 1 yr at 25°C. Thus, test chemical was considered to be stable in water.
On the basis of the experimental studies of the read across chemical and applying the weight of evidence approach and by evaluating the results, the hydrolysis half-life value of test chemical can be expected as >1 yr at 25°C/50°C and pH of 4, 7 and 9, respectively. Thus, test chemical was considered to be hydrolytically stable.
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