Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Adsorption and desorption:
The Adsorption Coefficient (Koc) of test chemical was determined by the Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method according to OECD Guideline No. 121 Adopted: 22 January 2001 for testing of chemicals. The analysis was performed at constant recommended conditions such as temperature 25°C (Methanol : Water) ratio 55:45 at the flow rate of 1 mL/min at 210 nm. Generalized reference substances were selected from OECD guideline 121. Selected reference substances and test chemical were prepared in methanol with the concentration of 400 mg/L. Both were analyzed on HPLC considering the similar conditions After analyzing on above conditions calibration curve of selected reference substances was prepared to obtain log Kocvalue.
The reference substances were 2-Nitrobenzamide, Acetanilide, Aniline, 3,5-Dinitrobenzamide, 4-Methyl benzyl alcohol, 1,2,3-Trichlorobenzene and Carbendazim having Log Kocvalue ranging from 1.5 to 5.5 TheLog Kocvalue was found to be2.978±0.016at 25°C.
Adsorption and desorption of the test chemical was done using the KOCWIN of EPI Suite, which was estimated to be 2.311 l/kg
Additional information
Adsorption and desorption:
The Adsorption Coefficient (Koc) of test chemical was determined by the Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method according to OECD Guideline No. 121 Adopted: 22 January 2001 for testing of chemicals. The analysis was performed at constant recommended conditions such as temperature 25°C (Methanol : Water) ratio 55:45 at the flow rate of 1 mL/min at 210 nm. Generalized reference substances were selected from OECD guideline 121. Selected reference substances and test chemical were prepared in methanol with the concentration of 400 mg/L. Both were analyzed on HPLC considering the similar conditions After analyzing on above conditions calibration curve of selected reference substances was prepared to obtain log Kocvalue.
The reference substances were 2-Nitrobenzamide, Acetanilide, Aniline, 3,5-Dinitrobenzamide, 4-Methyl benzyl alcohol, 1,2,3-Trichlorobenzene and Carbendazim having Log Kocvalue ranging from 1.5 to 5.5 TheLog Kocvalue was found to be2.978±0.016at 25°C.
Adsorption and desorption of the test chemical was done using the KOCWIN of EPI Suite, which was estimated to be 2.311 l/kg
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