Registration Dossier
Registration Dossier
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EC number: 260-300-4 | CAS number: 56634-95-8
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the Analogue Justification provided in IUCLID section 13
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 3.6 µg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- reproduction
- Remarks on result:
- other: Based on Bromoxynil octanoate reclaculated from Bromoxynil phenol
- Remarks:
- Source: M-241370-01-1
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.5 µg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- other: Bromoxynil phenol
- Basis for effect:
- reproduction
- Remarks on result:
- other:
- Remarks:
- Source: M-241370-01-1
Reference
Description of key information
From the source long-term key study, the 21-day NOEC for aquatic invertebrates exposed to the present test material was 0.0036 mg a.i./L in freshwater.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- ca. 0.004 mg/L
Additional information
Data on the long-term toxicity of the substance to aquatic invertebrates are not available. In accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. , the assessment is based on the structurally analogue substance (CAS 1689-99-2). Please refer to the attached analogue justification for further details on the read-across approach.
The long-term effects of the substance towards aquatic invertebrates were examined in a 21-day toxicity test with Daphnia magna under flow-through conditions (1991). The study was carried out according to GLP and EPA OPP 72-4 guidelines. Daphnia were exposed to nominal concentrations of 0.0025, 0.0036, 0.0086, 0.0175 and 0.0335 mg a.i./L, alongside with a control. Based on this study, the 21d NOEC reproduction for aquatic invertebrates exposed to test substance in the freshwater was 0.0036 mg a.i./L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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