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EC number: 260-300-4 | CAS number: 56634-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The PBT Assessment is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2017).
Persistence (P) Assessment
2,6-dibromo-4-cyanophenyl heptanoate (CAS 56634-95-8) is considered to be not readily biodegradable. based on data available for the structural analogue 2,6-dibromo-4-cyanophenyl octanoate (37 % b in 28 days; OECD 301B). The assessment of the biodegradation in water/sediment is based on data available for the structural analogue 2,6-dibromo-4-cyanophenyl octanoate in a simulation study, according to GLP and BBA Part IV. A degradation half-life ranging from 4.2 to 8.5 hours (recalculated to 12 °C) was determined for the read-across substance 2,6-dibromo-4-cyanophenyl octanoate. The main degradation product in water and sediment was 3,5-dibromo-4-hydroxybenzonitrile. After 100 days 14CO2 formation accounted for 55.2 and 55.4% AR. The degradation half-life of the main degradation product 3,5-dibromo-4-hydroxybenzonitrile ranged from 8.5 to 36 days (recalculated to 12 °C).
The degradation of the transformation product and structural analogue [14C]-3,5-dibromo-4-hydroxybenzonitrile (CAS 1689-84-5) was investigated in natural water samples under aerobic conditions. Under the conditions of the test 3,5-dibromo-4-hydroxybenzonitrile remained stable (DT50 = >1000 days).
The assessment of the biodegradation in soil is based on data available for the structural analogue 2,6-dibromo-4-cyanophenyl octanoate. A half-life of 0.14 – 0.62 days (0.28 – 1.25 days, recalculated to 12 °C) in three different soils was determined. After 35 days 29.4 – 55.1% of the applied radioactivity were mineralized.
Based on the available data on the degradation product 3,5-dibromo-4-hydroxybenzonitrile, the target substance 2,6-dibromo-4-cyanophenyl heptanoate is assessed as vP/P.
Bioaccumulation (B) assessment
The experimentally determined log Pow of 5.4 of 2,6-dibromo-4-cyanophenyl heptanoate (CAS 56634-95-8) indicates a potential for bioaccumulation. However, a study on the bioconcentration in fish, available for the structural analogue 2,6-dibromo-4-cyanophenyl octanoate (CAS 1689-99-2), determined a BCF of 180 ± 40 (whole fish). Based on the available read-across data 2,6-dibromo-4-cyanophenyl heptanoate does not meet the B criterion.
Toxicity (T) assessment
The substance is classified as H361d (“Suspected of damaging the unborn child”) and thus assessed as T.
Effect concentrations determined in chronic aquatic toxicity tests were < 0.01 mg/L.
Summary and overall conclusions on PBT or vPvB properties
Overall conclusion:
Based on the assessment described in the subsections above the substance is not PBT.
Justification:
According to Annex XIII of the REACH Regulation (EC) No 1907/2006, a PBT substance has to meet all three of the criteria for persistence, bioaccumulation and toxicity, as listed in part 1 of Annex XIII, and a vPvB substance has to meet all criteria for persistence and bioaccumulation, as listed in part 2 of Annex XIII. Based on the relevant data provided and discussed, the substance is identified as vP and T, the substance is not identified as PBT or vPvB.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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