Registration Dossier
Registration Dossier
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EC number: 203-996-7 | CAS number: 112-67-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Dose volumes extending the recommended amounts.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Palmitoyl chloride
- EC Number:
- 203-996-7
- EC Name:
- Palmitoyl chloride
- Cas Number:
- 112-67-4
- Molecular formula:
- C16H31ClO
- IUPAC Name:
- hexadecanoyl chloride
- Details on test material:
- - Name of test material (as cited in study report): Palmitinsaeurechlorid (=Palmitoyl chloride)
- Analytical purity: 98% (analytical report: ZAX96L00731, Jan. 1997)
- Lot/batch No.: Vers. 98
- Lot/batch No.: Vers. 62/V
- Storage condition of test material: room temperature, sensitive to moisture
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner
- Weight at study initiation: 232 ± 19 g (male), 187 ± 12 (female)
ENVIRONMENTAL CONDITIONS
not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous emulsion containing Traganth
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2, 20%
MAXIMUM DOSE VOLUME APPLIED: 32 ml/kg = maximum 7.9 ml/animal - Doses:
- 200, 1600, 3200 and 6400 µL/kg = ca. 180, 1440, 2880, 5760 mg/kg (calculated with a density of 0.9 g/mL)
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Weighing was only at the beginning of the study for dose calculation. Observation of clinical signs was several times on the day of administration and once daily afterwards except on weekends and on holidays.
- Necropsy of survivors performed: yes - Statistics:
- Not performed.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 760 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 6.4 mL/kg bw
- Mortality:
- 200 µL/kg: no mortality
1600 µL/kg: no mortality
3200 µL/kg: no mortality
6400 µL/kg: 1/20 animals died within 3 d - Clinical signs:
- other: 200 µL/kg: directly after application: squatting posture, depressed respiration; during observation period: piloerection reversible within 1 d 1600 µL/kg: directly after application: abdominal posture, very depressed respiration, semi-closed eye lids, ; p
- Gross pathology:
- nothing abnormal observed
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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