Registration Dossier
Registration Dossier
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EC number: 203-996-7 | CAS number: 112-67-4
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound palmitoyl chloride: No data.
Hydrolysis product palmitic acid: No toxic effect within range of water solubility.
Hydrolysis product HCl: No data.
Key value for chemical safety assessment
Additional information
Parent compound palmitoyl chloride (CAS 112 -67 -4):
No data are available for palmitoyl chloride (CAS 112 -67 -4). The substance rapidly decomposes in water and forms HCl (CAS 7647 -01 -0) and palmitic acid (CAS 57 -10 -3). Therefore, the long-term toxicity to aquatic invertebrates is assessed on the basis of data on palmitic acid.
Hydrolysis product palmitic acid (CAS 57 -10 -3):
For palmitic acid (CAS 57 -10 -3) two limit tests are available to assess the long-term toxicity towards aquatic invertebrates.
- A semi-static reproduction inhibtion test was performed with D. magna according to OECD 211 (limit test; GLP). The 21 -d NOEC was determined to be > 0.22 mg/L (measured time weighted mean concentrations, NITE, 2008, report no.: A050381).
- In a semi-static reproduction inhibition test with Daphnia magna according to OECD TG 211 (limit test; GLP), the 21 -d NOEC was determined to be > 5.8 mg/L (measured time weighted mean concentrations, NITE, 2000, report no.: NMMP/E99/3010).
The effect values determined in both studies are clearly above the water solubility for palmitic acid (WS = 0.04 mg/L, at 25 °C, Robb 1966, PhysProp database of EPI Suite v4.11).
In conclusion, chronic effects on aquatic invertebrates are not expected within the water solubility limit of palmitic acid.
Hydrolysis producthydrochloric acid (HCl; CAS 7647 -01 -0):
No data are available for HCl.
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