1,2,3,6-tetrahydro-3-methylphthalic anhydride

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Information published in peer reviewed journal

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Symptoms and immunologic markers induced by exposure to methyltetrahydrophthalic anhydride

Author:

Nielsen, J. et.al.

Year:

1994

Bibliographic source:

Allergy, (1994) 49 281-286

Materials and methods

Type of study / information:

Type of experience: Human

Endpoint addressed:

respiratory irritation

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

No information

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tetrahydromethylphthalic anhydride

EC Number:

234-290-7

EC Name:

Tetrahydromethylphthalic anhydride

Cas Number:

11070-44-3

IUPAC Name:

3a-methyl-3a,4,5,6-tetrahydro-2-benzofuran-1,3-dione

Details on test material:

- Name of test material (as cited in study report): MTHPA
- Molecular formula (if other than submission substance): C9 H10 O3
- Molecular weight (if other than submission substance): 166.18
- Smiles notation (if other than submission substance): O=C(OC(=O)C1CC=C(C2)C)C12
- InChl (if other than submission substance): 1/C9H10O3/c1-5-2-3-6-7(4-5)9(11)12-8(6)10/h2,6-7H,3-4H2,1H3
- Structural formula attached as image file (if other than submission substance): see Fig. (11070-44-3 structure.jpg)

Method

Ethical approval:

not specified

Details on study design:

no details given

Exposure assessment:

measured

Details on exposure:

TYPE OF EXPOSURE: inhalation
TYPE OF EXPOSURE MEASUREMENT: Personal sampling and Biomonitoring blood

Results and discussion

Results:

Ten workers sensitized to MTHPA (group SS; presence of serum IgE  antibodies against a conjugate of MTHPA and human serum albumin (HSA) detected by RAST had significantly higher levels of tryptase in nasal lavage fluid than 19 non sensitized workers with work-related nasal symptoms (group  NS) and 14 non sensitized workers without nasal symptoms.
(group NN).

Any other information on results incl. tables

Forty three workers exposed tetrahydromethyl-1,3-isobenzofuranedione (MTHPA) used as a hardener in an epoxy resin system were reported. Ten workers sensitized to MTHPA (group SS; presence of serum IgE antibodies against a conjugate of MTHPA and human serum albumin (HSA) detected by RAST had significantly higher levels of tryptase in nasallavage fluid than 19 non sensitized workers with work-related nasal symptoms (group NS) and 14 non sensitized workers without nasal symptoms (group NN). This result suggests an ongoing mast-cell-mediated reaction in the sensitized group.

Applicant's summary and conclusion

Conclusions:

This result suggests an ongoing mast-cell-mediated reaction in the sensitized group.

Executive summary:

Ten workers sensitized to MTHPA (group SS; presence of serum IgE antibodies against a conjugate of MTHPA and human serum albumin (HSA) detected by RAST had significantly higher levels of tryptase in nasal lavage fluid than 19 non sensitized workers with work-related nasal symptoms (group NS) and 14 non sensitized workers without nasal symptoms. This result suggests an ongoing mast-cell-mediated reaction in the sensitized group.