1,2,3,6-tetrahydro-3-methylphthalic anhydride

Biodegradation in water: screening tests

Link to relevant study record(s)

Reference

Endpoint:

biodegradation in water: screening test, other

Remarks:

Pathway modelling and biodegradability assessment

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

key study

Study period:

June 09, 2020

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Qualifier:

no guideline followed

Principles of method if other than guideline:

enviPath that is both a database and a prediction system for the microbial biotransformation of organic environmental contaminants. The database provides the possibility to store and view experimentally observed biotransformation pathways. The pathway prediction system provides different relative reasoning models to predict likely biotransformation pathways and products.
enviPath is a complete redesign and reimplementation of UM-BBD/PPS (University of Minnesota Biocatalysis/Biodegradation Database and Pathway Prediction System).
The UM-BBD/PPS was recently transferred to Eawag and renamed to EAWAG-BBD/PPS, available at http://eawag-bbd.ethz.ch/index.html. The system has been completely redesigned, reimplemented and therefore renamed enviPath (https://envipath.org/).

Parameter:

probability of ready biodegradability (QSAR/QSPR)

Value:

0.66

Remarks on result:

readily biodegradable based on QSAR/QSPR prediction

Remarks:

BIOWIN2

Parameter:

calculated rating of total degradation time (QSAR/QSPR)

Value:

2.83

Remarks on result:

readily biodegradable based on QSAR/QSPR prediction

Remarks:

BIOWIN3, Weeks

Parameter:

probability of ready biodegradability (QSAR/QSPR)

Value:

0.09

Remarks on result:

not readily biodegradable based on QSAR/QSPR prediction

Remarks:

BIOWIN6

Details on results:

The above results refer only to the test material. A more detailed biodegradation analysis, including the identified degradation products, is available in the attached full study report.

Validity criteria fulfilled:

yes

Interpretation of results:

inherently biodegradable

Conclusions:

Modelling of possible biodegradation pathways estimated by enviPath, according to the biotransformation rules, indicates that aerobic degradation of 1,2,3,6-tetrahydro-3-methylphthalic anhydride is likely; the degradation products were identified until two transformation levels.
All these substances were subjected to a Biodegradation screening assessment, according to the EPA BIOWIN 4.10 model.
According to the evaluation criteria set in the ECHA Guidances Chapters R.7b and R.11, 1,2,3,6-tetrahydro-3-methylphthalic anhydride was estimated as being inherently biodegradable and not potentially P or vP to the environment.

Executive summary:

1,2,3,6-tetrahydro-3-methylphthalic anhydride was estimated as being inherently biodegradable and not  potentially P or vP to the environment.

Description of key information

Primary degradation of the substance itself is rapid but significant ultimate degradation has not been demonstrated.

Modelling of possible biodegradation pathways estimated by enviPath, according to the biotransformation rules, indicates that aerobic degradation of 1,2,3,6-tetrahydro-3-methylphthalic anhydride is likely; the degradation products were identified until two transformation levels.

All these substances were subjected to a Biodegradation screening assessment, according to the EPA BIOWIN 4.10 model.

According to the evaluation criteria set in the ECHA Guidances Chapters R.7b and R.11, 1,2,3,6-tetrahydro-3-methylphthalic anhydride was estimated as being inherently biodegradable and not  potentially P or vP to the environment.

Key value for chemical safety assessment

Biodegradation in water:

inherently biodegradable