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EC number: 824-458-3 | CAS number: 1263679-68-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26/11/2016 - 17/02/2017
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (1Z)-1-chloro-2,3,3-trifluoroprop-1-ene
- EC Number:
- 824-458-3
- Cas Number:
- 1263679-68-0
- Molecular formula:
- C3H2ClF3
- IUPAC Name:
- (1Z)-1-chloro-2,3,3-trifluoroprop-1-ene
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Samples of the test solutions at the beginning and the end of the renewal period, i.e. when it is freshly prepared and immediately prior to renewal or at the end of exposure are referred to as one set. The two sets of test solutions, one at the beginning of exposure (0 hour) and before renewal at 24 hours and the other after renewal at 72 hours and at the end of exposure (96 hours), were analysed. The test solution of each test group was collected and analysed by gas chromatography/mass spectrometry (GC/MS).
Test organisms
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- Common name: Medaka
Scientific name: Oryzias latipes
Source: Breeding in the testing facility
Date of starting the collection of eggs: June 20, 2016
Lot No.: 16-M-0620B
Size: Total length: Recommended: 2.3 ± 1.2 cm; Measurements: 2.66 cm (2.39 - 3.03 cm), n=lO
Body weight: Measurements: 0.159 g (0.089- 0.241 g), n=lO; (Measurements of fish in the control group were made post-exposure)
Sensitivity to reference substance: The sensitivity of test fish has been confirmed in each lot by the acute toxicity test of reference substance (CuS04(II)· 5H20, guaranteed reagent). The 96-hour median lethal concentration (96-hour LC50, in anhydrous) is shown below:
- 96-hour LC50 of the lot concerned (Date of performing the acute toxicity test: October 7, 2016)
- 0.26 mg/L (95% confidence limits: 0.10 - 0.40 mg/L)
-The average LC50 value in this laboratory (n = 80, since 1995); Average± standard deviation: 0. 73 ± 0.29 mg/L; Minimum value - maximum value: 0.28 - 1.5 mg/L
Age: Less than a half year after hatching
Medication before acclimation: Applied (New Green F, San-ei Pharmaceutical Co. Ltd.)
Acclimation period: November 24, 2016 - December 5, 2016
Acclimation conditions:
- Water: Dechlorinated water
- Procedure: Flow-through (Biomass loading: 1 g fish/L/day or less)
- Temperature: 24 ± 1 °C
- Dissolved oxygen concentration (D.O.): 80% or more of the saturation
- pH: 6.0-8.5
- Light: Fluorescent light, 16-hour light (1000 lux or less) I 8-hour dark
- Feed: TetraMin, TetraWerke
- Feeding amount: 2% of the body weight/day (approx.) (until 24 hours before exposure)
- Medication during acclimation: Not applied
- Mortality during 7 days before the test: Less than 5%
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 47 mg CaCO3/L
- Test temperature:
- 23.7 - 24.0
- pH:
- 6.8 - 7.5
- Dissolved oxygen:
- 5.0 - 8.8 mg/L
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 110 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 76.1 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Acute toxicity test of the test substance with Medaka ( Oryzias latipes) was conducted using a binomial method in order to determine the median lethal concentration (LC50) of the test substance for 96-hour exposure. This was determined to be 110 mg/L (95% confidence limits: 76.1 - ∞ mg/L by binomial method).
- Executive summary:
Acute toxicity test of the test substance with Medaka ( Oryzias latipes) was conducted using a bonomial method in order to determine the median lethal concentration (LC50) of the test substance for 96-hour exposure. This was determined to be 110 mg/L (95% confidence limits: 76.1 - ∞ mg/L)
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