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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

water solubility
Type of information:
Adequacy of study:
other information
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Data source

Referenceopen allclose all

Reference Type:
other: QSAR-tool
Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.11: (WSKOW v1.42)
United States Environmental Protection Agency, Washington, DC, USA.
Bibliographic source:
Reference Type:
review article or handbook
Exploring QSAR - Hydrophobic, Electronic, and Steric Constants
Hansch, C., Leo, A., D. Hoekman
Bibliographic source:
Washington, DC: American Chemical Society., 1995

Materials and methods

Principles of method if other than guideline:
WSKOW accepts experimental Log Kow and MP values, and its accuracy greatly improved if an experimental MP is entered.

Results and discussion

Water solubility
Key result
Water solubility:
47 850 mg/L
25 °C

Any other information on results incl. tables

Water Sol from Kow (WSKOW v1.42) Results:



Water Sol: 4.785e+004 mg/L


SMILES : c1ccc(cc1)S(=O)(=O)NN

CHEM  : Benzenesulphonohydrazide

MOL FOR: C6 H8 N2 O2 S1

MOL WT : 172.20

---------------------------------- WSKOW v1.42 Results ------------------------

Log Kow (estimated) : 0.01

Log Kow (experimental): -0.14

Cas No: 000080-17-1


Refer : HANSCH,C ET AL.(1995)

Log Kow used by Water solubility estimates: 0.00 (user entered)


Equation Used to Make Water Sol estimate:

Log S (mol/L) = 0.693-0.96 log Kow-0.0092(Tm-25)-0.00314 MW + Correction


Melting Pt (Tm) = 102.00 deg C (Use Tm = 25 for all liquids)


Correction(s):        Value

--------------------  -----

No Applicable Correction Factors


Log Water Solubility (in moles/L) : -0.556

Water Solubility at 25 deg C (mg/L): 4.785e+004

Applicant's summary and conclusion