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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

short-term toxicity to fish
Type of information:
Adequacy of study:
other information
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Data source

Reference Type:
other: QSAR-tool
Estimation Program Interface EPI Suite (TM) v4.11: ECOSAR v1.11
United States Environmental Protection Agency, Washington, DC, USA.
Bibliographic source:

Materials and methods

Principles of method if other than guideline:
ECOSAR™ Version 1.11 (Sept 2012): The Ecological Structure Activity Relationships (ECOSAR) Class Program estimates the aquatic toxicity of industrial chemicals. The program estimates acute (short-term) toxicity and chronic (long-term or delayed) toxicity to aquatic organisms to fish, aquatic invertebrates and green algae.
GLP compliance:

Results and discussion

Effect concentrations
Key result
96 h
Dose descriptor:
Effect conc.:
1 369.188 mg/L
Basis for effect:
mortality (fish)

Any other information on results incl. tables

Sublethal observations / clinical signs:

ECOSAR Program (v1.11) Results:


ECOSAR Version 1.11 Results Page


SMILES : c1ccc(cc1)S(=O)(=O)NN

CHEM  : Benzenesulphonohydrazide

CAS Num:


MOL FOR: C6 H8 N2 O2 S1

MOL WT : 172.20

Log Kow: 0.007     (EPISuite Kowwin v1.68 Estimate)

Log Kow:           (User Entered)

Log Kow: -0.14     (PhysProp DB exp value - for comparison only)

Melt Pt: 102.00    (deg C, User Entered for Wat Sol estimate)

Melt Pt: 102.00    (deg C, PhysProp DB exp value for Wat Sol est)

Wat Sol: 6.521E+004 (mg/L, EPISuite WSKowwin v1.43 Estimate)

Wat Sol: 1.5E+004  (mg/L, User Entered)

Wat Sol:           (PhysProp DB exp value)




Values used to Generate ECOSAR Profile


Log Kow: 0.007     (EPISuite Kowwin v1.68 Estimate)

Wat Sol: 1.5E+004  (mg/L, User Entered)





ECOSAR v1.11 Class-specific Estimations




ECOSAR Class                Organism           Duration End Pt  mg/L (ppm)

=========================== ================== ======== ======  ==========

Amides                    : Fish               96-hr    LC50    1369.188

Amides                    : Daphnid            48-hr    LC50    3776.089

Amides                    : Green Algae        96-hr    EC50      28.011

Amides                    : Fish                         ChV        0.718

Amides                    : Daphnid                      ChV       56.830

Amides                    : Green Algae                  ChV       11.351

Amides                    : Fish (SW)          96-hr    LC50    1185.207

Amides                    : Mysid (SW)         96-hr    LC50      39.973


=========================== ================== ======== ======  ==========

Neutral Organic SAR       : Fish               96-hr    LC50    8718.941

(Baseline Toxicity)       : Daphnid            48-hr    LC50    4118.588

: Green Algae        96-hr    EC50    1433.592

: Fish                         ChV      685.961

: Daphnid                      ChV      240.680

: Green Algae                  ChV      249.207


Note: * = asterisk designates: Chemical may not be soluble enough to

measure this predicted effect. If the effect level exceeds the

water solubility by 10X, typically no effects at saturation (NES)

are reported.




Class Specific LogKow Cut-Offs


If the log Kow of the chemical is greater than the endpoint specific cut-offs

presented below, then no effects at saturation are expected for those endpoints.


Amides :


Maximum LogKow: >8.5 (LC50)

Maximum LogKow: >8.0 (EC50,ChV)


Baseline Toxicity SAR Limitations:


Maximum LogKow: 5.0 (Fish 96-hr LC50; Daphnid LC50)

Maximum LogKow: 6.4 (Green Algae EC50)

Maximum LogKow: 8.0 (ChV)

Applicant's summary and conclusion