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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1995
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well performed OECD study following the GLP principles
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
not specified
GLP compliance:
yes
Remarks:
without GLP inspection
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
TEST ORGANISM
- Common name: Zebrabi:irbling
- Strain: HAMILTON-BUCHANAN
- Source: HOECHST AG, Kastengrund
- Length at study initiation: average 3.0 cm +-0.23
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Test temperature:
21.3 - 22.7 °C
pH:
7.9 - 8.4
Dissolved oxygen:
7.2 - 9.6 mg/L
Nominal and measured concentrations:
Nominal concentrations:
0/2,2/5/10/22/50/100/220/500/1000 mg/L
Reference substance (positive control):
not specified
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
2.2 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
24 h
Dose descriptor:
LC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
24 h
Dose descriptor:
LC0
Effect conc.:
1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Sublethal observations / clinical signs:

At all concentrations above 2,2 mg/L 1 - 2 fish were found dead. Letality was often delayed and showed no dependence to the concentration of the test item. In all concentrations tested there was influence on the swimming behaviour and breathing observed.

No concentration dependend toxic symptoms. Due to poor water solubility these effects may be caused by not dissolved parts of the test item

Validity criteria fulfilled:
not specified
Conclusions:
LC50 > 1000 mg/L
Executive summary:

The substance was tested for toxicity to fish according to OECD guideline 203 in concentrations of 0/2,2/5/10/22/50/100/220/500/1000 mg/L. Summarizung the individual results the LC50 of the substance can be determined as LC50 > 1000 mg/L.

Description of key information

The substance was tested for toxicity to fish according to OECD guideline 203 in concentrations of 0/2,2/5/10/22/50/100/220/500/1000 mg/L. Summarizung the individual results the LC50 of the substance can be determined as LC50 > 1000 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
1 000 mg/L

Additional information