bis(O,O-2-ethylhexyl-thiophosphoryl)polysulfide

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-05-11 - 2017-10-19 (experimental phase)

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Remarks:

Water solubility

Reason / purpose for cross-reference:

reference to same study

Remarks:

Adsorption / Desorption

Qualifier:

according to guideline

Guideline:

other: EU method A.24

Version / remarks:

EC Guideline A.24. Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method. March 1, 2016

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Version / remarks:

OECD Guideline 117. Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method. April 13, 2004.

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)

Version / remarks:

EPA Product Properties Test Guideline OPPTS 830.7570: Partition Coefficient
(n-octanol/water), Estimation by Liquid Chromatography. August 1996.

Deviations:

no

GLP compliance:

yes

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: sponsor

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: In refrigerator (2-8°C)

Analytical method:

high-performance liquid chromatography

mass spectrometry

Type:

log Pow

Partition coefficient:

6.5

Temp.:

35 °C

Remarks on result:

other: Peak 1, minor constituent

Remarks:

neutral pH

Key result

Type:

log Pow

Partition coefficient:

> 7.2

Temp.:

35 °C

Remarks on result:

other: Peak 2-24, major constituent

Remarks:

neutral pH

Conclusions:

The study was performed according to OECD TG 117 under GLP on the substance to be registered itself, the test procedure is well documented and therefore reliability of Klimisch 1 has been assigned. The analytical method was properly established.
The HPLC method at neutral pH was applied for the determination of the partition coefficient (Pow) of the test item. The test item – peak 2 – 24, i.e. the major components, gave a logPow > 7.2 (peak 1, minor component, logPow = 6.5). It can hence be expected that the actual logPow is much higher, a preliminary estimation for the trisulfide gave a logPow = 17.5 using the Rekker calculation method, and the substance is practically insoluble in water.

Executive summary:

The Partition coefficient (octanol/water) of the test item was determined according to EC A.24, OECD 117, OPPTS 830.7570 under GLP using the HPLC method to logPow : > 7.2 (major component).

Description of key information

Partition coefficient (octanol/water): logPow > 7.2 (major component)(EC A.24, OECD 117, OPPTS 830.7570, GLP, HPLC method)

Key value for chemical safety assessment

Log Kow (Log Pow):

7.2

at the temperature of:

35 °C

Additional information

The HPLC method at neutral pH was applied for the determination of the partition coefficient (Pow) of the test item. The test item – peak 2 – 24, i.e. the major components, gave a logPow > 7.2 (peak 1, minor component, logPow = 6.5). It can hence be expected that the actual logPow is much higher, a preliminary estimation for the trisulfide gave a logPow = 17.5 using the Rekker calculation method, and the substance is practically insoluble in water.