bis(O,O-2-ethylhexyl-thiophosphoryl)polysulfide

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

short-term repeated dose toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
According to REACH Annex VIII column 1 (8.6.1), the following study for repeated dose toxicity is required: Short-term repeated dose toxicity study (28 days), one species, male and female, most appropriate route of administration, having regard to the likely route of human exposure. There is a suitable Klimisch 1 GLP OECD 422 guideline study available, assessing the toxicological properties of the registered substance after oral gavage over 6-7 weeks. In general, the oral route is the most suitable one to assess systemic effects in humans, which is the main aim of this endpoint. The dermal or inhalative route is only scientifically relevant in case of considerable exposure, any route-specific toxicological mode of action or local effects, whereas sufficient information on the latter can be gained via irritation tests (REACH No. 8.1. or 8.2). According to REACH Annex VIII column 2 (8.6.1), testing by the inhalation route is appropriate if exposure of humans via inhalation is likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size.
The vapour pressure of the substance was determined to be 3.5x10-5 Pa and 7.1x10-5 Pa at 20°C (293K) and 25°C (298K) (isothermal TGA effusion method, OECD 104). According to the BG Bau [BG Bau 2017; Berufsgenossenschaft der Bauwirtschaft, http://www.bgbau.de/gisbau/lehrgang/a-z/dampfdru.htm, download of 2017-09-08], a vapour pressure of p < 0.01 hPa (i.e. 1 Pa) is very low, p = 1-10 hPa low and p > 10 hPa is high. The 31. BImSchV describes an organic substance as volatile if it has a vapour pressure of 0.01 kPa (i.e. 10 Pa) or more at 293.15 K. Also, according to ECHA’s guidance, substances are not available for inhalation as a gas in a relevant manner with a vapour pressure less than 0.5 kPa (i.e. 500 Pa) (or a boiling point above 150°C) [ECHA, 2008]. With a boiling point of 215°C and a vapour pressure of 7.1 x 10E-5 Pa at 25°, the registered substance has a very low vapour pressure and does not need to be regarded a volatile. Hence, the potential inhalation of the substance as a gas is not given and does not need to be regarded. Further, sufficient precautionary measures exclude the formation of droplets of inhalable size or aerosols. In consequence, exposure of humans via inhalation is not likely, hence not fulfilling the criteria for the necessity of testing via inhalation route.
Further, no route-specific toxicity can be expected, and it is considered more reasonable to focus on the assessment of systemic toxicity, which can be best performed using the oral application route. In consequence, the available OECD 422 study (oral exposure route) is sufficient to cover this endpoint, no repeated dose testing via inhalation route needs to be performed and can consequently be waived due to animal welfare.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

data waiving: supporting information

Remarks:

physical state

Reference

Endpoint:

appearance / physical state / colour

Type of information:

other: observation

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: acceptable company statement (specification data on manufactured product requires strict adherence to conform within range and so is reliable)

Qualifier:

no guideline followed

Principles of method if other than guideline:

- Visual description of the colour (in daylight by an observer with normal colour vision) and the physical state (at 20°C and 1013 hPa)
- Determination of the odour at room temperature and comparison to other substances of characteristic odours

GLP compliance:

no

Physical state at 20°C and 1013 hPa:

liquid

Key result

Form:

liquid

Colour:

orange

Odour:

characteristic of sulfur-containing compounds

Substance type:

organic

Conclusions:

The determination of the test items appearance / physical state / colour was determined scientifically reasonably by visual inspection at 20°C. There is no indication given that the results are not reliable.
- physical state at 20°C and 1013 hPa: liquid
- colour: orange
- odour: characteristic

Executive summary:

The visual description of the colour, the physical state (at 20°C and 1013 hPa) and the determination of the odour resulted in the following: test substance is a orange liquid with a characteristic odour.

Cross-reference 2

Reason / purpose for cross-reference:

data waiving: supporting information

Remarks:

melting point

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

non-GLP

Qualifier:

according to guideline

Guideline:

other: DIN 51007

Deviations:

not specified

Qualifier:

according to guideline

Guideline:

other: ASTM D 3418-99

Deviations:

not specified

GLP compliance:

no

Type of method:

differential scanning calorimetry

Key result

Melting / freezing pt.:

< -20 °C

Decomposition:

no

Sublimation:

no

Remarks on result:

other: no information on atm. pressure available

Conclusions:

The study was performed according to DIN 51007 & ASTM D 3418-99 on the substance to be registered itself, the test procedure is well documented and therefore reliability of Klimisch 2 has been assigned. No melting point was observed below a lower limit of -20 °C.

Executive summary:

The melting point of the test substance was determined by DSC in a study according to DIN 51007 & ASTM D 3418-99. No melting point was observed below a lower limit of -20 °C, hence, the melting point is < -20°C.

Cross-reference 3

Reason / purpose for cross-reference:

data waiving: supporting information

Remarks:

boiling point

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-05-04 - 2017-05-05 (experimental phase)

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point/Boiling Range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Remarks:

A measurement with the capillary method was performed to clarify the results of the DSC measurements.

Specific details on test material used for the study:

- Storage condition of test material: Ambient temperature (10 °C to 30 °C)

Key result

Boiling pt.:

>= 215 °C

Decomposition:

yes

Remarks on result:

other: The test item boiled under decomposition starting at 215 °C (atmospheric conditions). The decomposition started before boiling occurred.

Conclusions:

The boiling temperature was determined according to a scientifically valid method, i.e. EU method A.2 under GLP, in a well-documented study, hence, the following result for the test material can be considered as reliable: The test item boiled under decomposition starting at 215 °C (atmospheric conditions). The decomposition started before boiling occurred.

Executive summary:

The purpose of this study was the determination of the boiling point of bis(O,O-2-ethylhexyl-thiophosphoryl)polysulfide according to European Commission Regulation (EC) No. 440/2008, A.2. Boiling point / boiling range and OECD test guideline, OECD 103 Boiling point / boiling range.

Under consideration of the results from the thermal stability (ambiguous onset) and the capillary method it was concluded that the test item boiled under decomposition starting at 215 °C. The decomposition started before boiling occurred.

Cross-reference 4

Reason / purpose for cross-reference:

data waiving: supporting information

Remarks:

vapour pressure

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-06-22 - 2017-08-04 (experimental phase)

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

EC Guideline A.4. Vapour Pressure. August 24, 2009

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

OECD Guideline104. Vapour Pressure. March 23, 2006

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Version / remarks:

EPA Product Properties Test Guideline OPPTS 830.7950: Vapor pressure. August 1996.

Deviations:

no

GLP compliance:

yes

Type of method:

effusion method: isothermal thermogravimetry

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: sponsor

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: In refrigerator (2-8°C)

Key result

Temp.:

20 °C

Vapour pressure:

0 Pa

Remarks on result:

other: 2.6E-7 mmHg

Key result

Temp.:

25 °C

Vapour pressure:

0 Pa

Remarks on result:

other: 5.3E-7 mmHg

Conclusions:

The study was performed according to OECD TG 104 under GLP on the substance to be registered itself, the test procedure is well documented and therefore reliability of Klimisch 1 has been assigned. The isothermal TGA effusion method was applied for the determination of the vapour pressure of the test item. The vapour pressure of the test item at 20°C (293K) and 25°C (298K) was 3.5 x 10-5 Pa and 7.1 x 10-5 Pa, respectively.

Executive summary:

The isothermal TGA effusion method was applied for the determination of the vapour pressure of the test item acc. OECD TG 104 under GLP. The vapour pressure of the test item at 20°C (293K) and 25°C (298K) was 3.5x10^-5 Pa and 7.1x10^-5 Pa, respectively.