Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Justification for type of information:
ANALOGUE APPROACH JUSTIFICATION
Please refer to attached document
Qualifier:
according to guideline
Guideline:
other: Provisional Procedure: extended toxicology test with Daphnia magna (determination of NOEC for reproduction rate, mortality and the time of the first appearance of offspring; 21 d)
Deviations:
no
GLP compliance:
not specified
Analytical monitoring:
not specified
Test organisms (species):
Daphnia magna
Details on test organisms:
TEST ORGANISM
- Common name: Daphnid
- Strain/clone: Daphnia magna
- Feeding during test
- Food type: Tetramin-Hauptfutter (fish feed) and activated sludge
- Frequency: in open test vessels: daily; in closed test vessels: the days on which the parent animals were transferred

ACCLIMATION
- Acclimation period:
- Acclimation conditions (same as test or not):
- Type and amount of food: dry algae of the Scenedesmus genus (9 g food/ 1000 ml tap water)
- Feeding frequency: daily

Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
21 d
Hardness:
16°
Test temperature:
25°C
Nominal and measured concentrations:
Nominal: 0.025-25 mg/l range
Details on test conditions:
TEST SYSTEM
- Type: open 400-ml vessels containing 250 ml of test solution and covered with watch glasses..
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4

VEHICLE CONTROL PERFORMED: not relevant
Reference substance (positive control):
yes
Remarks:
potassium dichromate
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
3.2 mg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
reproduction
Remarks:
+ parent mortality + appearance of the first offspring
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
26 mg/L
Nominal / measured:
nominal
Conc. based on:
not specified
Basis for effect:
mortality
Duration:
24 h
Dose descriptor:
other: EC0
Effect conc.:
11 mg/L
Nominal / measured:
nominal
Conc. based on:
not specified
Basis for effect:
mortality
Results with reference substance (positive control):
21d-NOEC=0.05 mg/l
Validity criteria fulfilled:
yes
Conclusions:
The long-term toxicity of diallyl phthalate to Daphnia magna is characterised by a 21-d NOEC value of 3.2 mg/l for reproductive capacity, appearance of first brood and parental mortality.

Description of key information

DAIP read-across from DAP; The key information is based on a peer reviewed published study performed under the supervision of the German authorities. Acute toxicity was in agreement with data from a GLP study reported elsewhere in this file.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
3.2 mg/L

Additional information

The long-term toxicity of DAIP to Daphnia magna is characterised by a 21-d NOEC value of 3.2 mg/l for reproductive capacity, appearance of first brood and parental mortality read-across from a test on DAP.