Registration Dossier
Registration Dossier
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EC number: 214-122-9 | CAS number: 1087-21-4
Endpoint summary
Administrative data
Description of key information
Acute Fish Toxicity Study
The 96hr LC50 end point for DAP has been determined to be 0.23 mg/L. The 96h LC50 for DAIP has been determined to be 0.118 mg/L. This is 50% lower than the value for DAP so the ecotoxicity for DAIP can be predicted to be more toxic to DAP. However, this does not change the classification. DAP and DAIP are Aquatic Acute 1 as they both have 96h LC50 <= 1 mg/l.
The chemistry of the substances has already been shown to be similar. Although DAIP has a slightly lower water solubility than DAP the difference is unlikely to affect the end point of the study. However DAIP is more likely to hydrolyse quicker in water releasing allyl alcohol and hence the higher toxicity.
Justification for the use of read-across.
The physicochemical results demonstrate that the two substances are very similar. DAP and DAIP are both fairly soluble and have very similar log Pow values; DAP, 3.23 and DIAP, 3.36. These are important results as the Acute Fish Study is a crucial marker in determining the use of read-across for the aquatic compartment.
It is on this basis that it is proposed that DAP is a suitable read-across substance for DIAP for aquatic endpoints.
Additional information
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