Registration Dossier
Registration Dossier
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EC number: 204-259-2 | CAS number: 118-55-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Allergic contact dermatitis to various salols (phenyl salicylates). A structure-activity relationship study in man and in animal (guinea pig).
- Author:
- Bernard MarchandPierre BarbierGeorges DucombsJean FoussereauPierre MartinClaude Benezra
- Year:
- 1 981
- Bibliographic source:
- Archives of Dermatological Research, March 1981, Volume 272, Issue 1–2, pp 61–66
Materials and methods
Results and discussion
Any other information on results incl. tables
As reported by Marchand B.et al.in 1982, the sensitizing properties of salol (phenyl salicylate) were not well-documented. The only studies of experimental sensitization were those of Kligman in his Maximization test. In these studies the absence of sensitization in man (on 25 patients) was concluded, and salol was classed in group I (weak or nonallergens). This study shows the sensitizing power of phenyl salicylates in man, a result which was not expected from the maximization test. This study shows clearly that experimental sensitization to salol in guinea pigs is also feasible.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- The sensitizing properties of salol (phenyl salicylate) were not well-documented. The only studies of experimental sensitization were those of Kligman in his Maximization test. In these studies the absence of sensitization in man (on 25 patients) was concluded, and salol was classed in group I (weak or nonallergens). This study shows the sensitizing power of phenyl salicylates in man, a result which was not expected from the maximization test. This study shows clearly that experimental sensitization to salol in guinea pigs is also feasible.
Therefore, the substance is classified as Skin Sens. 1 H317.
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