Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-259-2 | CAS number: 118-55-8
Endpoint summary
Administrative data
Description of key information
Rat oral LD50 of phenyl salicylate is 3000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Effect level:
- 3 000 mg/kg bw
- Other findings:
- SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD - Interpretation of results:
- GHS criteria not met
- Remarks:
- CLP criteria not met
- Conclusions:
- Rabbit, oral, LDLo = 3000 mg/kg bw.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 000 mg/kg bw
- Based on:
- not specified
- Interpretation of results:
- other: CLP Regulation criteria not met.
- Conclusions:
- Rat, oral LD50 of phenyl salicylate is 3000 mg/kg bw.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Acute toxicity - oral route
Overall, available data are conclusive but not sufficient for the classification of the substance.
Specific target organ toxicity after single exposure
In the safety data sheet of the U.S. Pharmacopeial convention the substance, identified as Salicylic acid phenyl ester, is classified (according to GHS) for specific target organ toxicity, single exposure Category 3, respiratory tract irritation. In section 11, only generic information is reported: "Respiratory tract irritation.". Overall, available information is inconclusive for the classification of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
