Registration Dossier
Registration Dossier
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EC number: 423-740-1 | CAS number: 10461-98-0
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish:
In short term toxicity study of test chemical 2-cyclohexylidene-2-phenylacetonitrile on Oncorhynchus mykiss in semi static condition for 24, 48, 72 and 96 hrs. with mortality effects 50% lethal concentration (LC50) was found to be as follows:
LC50=2.5 mg/L (24 hrs.)
LC50=2.3 mg/L (48 hrs.)
LC50=1.8 mg/L (72 hrs.)
LC50=0.6 mg/L (96 hrs.)
LC100=> 1 mg/L (96 hrs.)
NOEC<= 0.16 mg/L (96 hrs.)
All these experimental values indicate that the test substance 2-cyclohexylidene-2-phenylacetonitrile categorized in aquatic category 1 and 2 as per the CLP criteria.
Supporting study from predicted model also estimate the LC 50 as1.41 mg/l in a 96 hrs.This LC50 value indicate that the test substance 2-cyclohexylidene-2-phenylacetonitrile is toxic to aquatic environment and categorized in Chronic Category 2.
Short-term toxicity to aquatic invertebrates:
In Short term toxicity to aquatic invertebrates Daphnia Magna of test substance 2-cyclohexylidene-2-phenylacetonitrile for 24 and 48 hrs.the effect concenttration (EC50) was found as followed:
EC50=3.5 mg/L (24 h)
EC50=2.3 mg/L (48 h)
EC100=> 3 mg/L (48 h)
NOEC=1.4 mg/L (48 h)
All experimental values indicate that the test substance2-cyclohexylidene-2-phenylacetonitrile was categorized in aquatic category 2 as per the CLP criteria.
Toxicity to aquatic algae and cyanobacteria:
In aquatic algae toxicity study for 72 hrs. on Scenedesmus capricornutum species the effective concentration was found to as followed:
EC50=0.86 mg/L (72 h) at biomass effect
EC50=1.96 mg/L (72 h) at growth rate effect
NOEC=0.5 mg/L(72 h) at growth rate effect
NOEC=0.5 mg/L(72 h) at biomass effect
All experimental values indicate that the test substance2-cyclohexylidene-2-phenylacetonitrile was categorized in aquatic category 1 and 2 as per the CLP criteria.
Supporting study from predicted model (ECOSAR v1.1 )indicate that the Effect concentration (EC50) for the test compound 2-cyclohexylidene-2-phenylacetonitrile in a 96h study using green algae is 1.771 mg/L.
This EC50 values indicate that the test substance is toxic to aquatic environment and catogerized in aquatic chronic 2 as per the CLP criteria.
Toxicity to microorganisms:
In micro organism toxicity study by OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test) for 3 hrs. resulted as followed:
IC50=> 3159 mg/L (3 h)
NOEC=> 3159 mg/L (3h)
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