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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

From experimental study it is concluded that the test substance 2-cyclohexylidene-2-phenylacetonitrile non irritating to skin and eye.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from test report
Qualifier:
according to guideline
Guideline:
other: 92/69/EEC
GLP compliance:
yes
Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
No details available
Type of coverage:
semiocclusive
Preparation of test site:
not specified
Vehicle:
other: The undiluted test material was used
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
4 h
Observation period:
No data
Number of animals:
3
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: mean score 1
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: mean score 2
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: mean score 3
Irritation parameter:
erythema score
Remarks on result:
other: Max. duration: d; Max. value at end of observation period: 0 (related to all animals)
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: other details not available
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: other details not available
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: other details not available
Irritation parameter:
edema score
Remarks on result:
other: Max. duration: d; Max. value at end of observation period: 0 (related to all animals)
Other effects:
No signs of irritation were noted at any time.
Interpretation of results:
not irritating
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
In skin irritation study erythema and edema score observed for overall at 24, 48 and 72 h in 3 New Zealand White rabbits at dose concentration of 500 mg resulted score .Thus it can be concluded that the test substance 2-cyclohexylidene-2-phenylacetonitrile is non irritating to skin.
Executive summary:

In skin irritation study erythema and edema score observed for overall at 24, 48 and 72 h in 3 New Zealand White rabbits at dose concentration of 500 mg resulted score .Thus it can be concluded that the test substance 2-cyclohexylidene-2-phenylacetonitrile is non irritating to skin.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from test report
Qualifier:
according to guideline
Guideline:
other: 92/69/EEC
GLP compliance:
yes
Species:
rabbit
Strain:
New Zealand White
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
0.1 ML
Duration of treatment / exposure:
No data
Observation period (in vivo):
No data
Number of animals or in vitro replicates:
3
Irritation parameter:
conjunctivae score
Remarks:
redness
Basis:
animal #1
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: mean score 1
Irritation parameter:
conjunctivae score
Remarks:
redness
Basis:
animal #2
Time point:
other: overall at 24, 48 and 72 h
Score:
1
Remarks on result:
other: mean score 2
Irritation parameter:
conjunctivae score
Remarks:
redness
Basis:
animal #3
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: mean score 3
Irritation parameter:
conjunctivae score
Remarks:
redness
Score:
1
Remarks on result:
other: Max. duration: 24 h; Max. value at end of observation period: 0 (related to all animals)
Irritation parameter:
chemosis score
Basis:
animal #1
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: mean score 1
Irritation parameter:
chemosis score
Basis:
animal #2
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: mean score 2
Irritation parameter:
chemosis score
Basis:
animal #3
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: mean score 3
Irritation parameter:
chemosis score
Score:
0
Remarks on result:
other: Max. duration: h; Max. value at end of observation period: 0 (related to all animals)
Irritation parameter:
cornea opacity score
Basis:
animal #1
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: mean score 1
Irritation parameter:
cornea opacity score
Basis:
animal #2
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: mean score 2
Irritation parameter:
cornea opacity score
Basis:
animal #3
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: mean score 3
Irritation parameter:
cornea opacity score
Score:
0
Remarks on result:
other: Max. duration: h; Max. value at end of observation period: 0 (related to all animals)
Irritation parameter:
iris score
Basis:
animal #1
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: mean score 1
Irritation parameter:
iris score
Basis:
animal #2
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: mean score 2
Irritation parameter:
iris score
Basis:
animal #3
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Remarks on result:
other: mean score 3
Irritation parameter:
iris score
Score:
0
Remarks on result:
other: Max. duration: h; Max. value at end of observation period: 0 (related to all animals)
Irritant / corrosive response data:
Reversibility of any observed effect: Changes fully reversible within 1 days
Other effects:
Moderate watery discharge from the eyes of all rabbits was noted at one hour only. Two rabbits showed slight reddening of the conjunctiva at one hour.
Interpretation of results:
not irritating
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
Test substance 2-cyclohexylidene-2-phenylacetonitrile was not irritating to rabbit eyes.
Executive summary:

In eye irritation experimental study on 3 New Zeland white rabbit at dose concentration of 0.1 ml applied and observed for 24, 48 and 72 hrs respectively.

In study conjunctivae (redness), chemosis , cornea , iris score become 0.This scoring system indicate that the test substance 2-cyclohexylidene-2-phenylacetonitrile is non irritating to eye.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation / corrosion:

In skin irritation study erythema and edema score observed for overall at 24, 48 and 72 h in 3 New Zealand White rabbits at dose concentration of 500 mg resulted score .Thus it can be concluded that the test substance 2-cyclohexylidene-2-phenylacetonitrile is non irritating to skin.

Eye irritation:

In eye irritation experimental study on 3 New Zeland white rabbit at dose concentration of 0.1 ml applied and observed for 24, 48 and 72 hrs respectively.

In study conjunctivae (redness), chemosis , cornea , iris score become 0.This scoring system indicate that the test substance 2-cyclohexylidene-2-phenylacetonitrile is non irritating to eye.


Justification for selection of skin irritation / corrosion endpoint:
In skin irritation study erythema and edema score observed for overall at 24, 48 and 72 h in 3 New Zealand White rabbits at dose concentration of 500 mg resulted score .Thus it can be concluded that the test substance 2-cyclohexylidene-2-phenylacetonitrile is non irritating to skin.

Justification for selection of eye irritation endpoint:
In eye irritation experimental study on 3 New Zeland white rabbit at dose concentration of 0.1 ml applied and observed for 24, 48 and 72 hrs respectively.
In study conjunctivae (redness), chemosis , cornea , iris score become 0.This scoring system indicate that the test substance 2-cyclohexylidene-2-phenylacetonitrile is non irritating to eye.

Justification for classification or non-classification

On the basis of available experimental data, the substance 2-cyclohexylidene-2-phenylacetonitrile is consider to be non irritating to skin and eye. It is thus not consider for further classification as per CLP criteria.