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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from safety assessment reports
Qualifier:
according to guideline
Guideline:
other: This study was conducted in compliance with OECD Guideline 105 and in accordance with the EPA GLP standards (40 CFR 160).
Principles of method if other than guideline:
Preliminary solubility data indicated that the sample was miscible in two of the solvents to be tested: water and isopropanol. Therefore, the OECD method was modified for these solvents by equilibrating weight: weight (1:1) mixtures of sample and solvent at 25°C for 24 h
GLP compliance:
not specified
Type of method:
flask method
Specific details on test material used for the study:
Name of test material (as cited in study report): 2-[(Hydroxymethyl)amino] ethanol
Molecular formula: C3H9NO2
Molecular weight: 91.1091 g/mol
Smiles notation: CN(CCO)O
InChI: 1S/C3H9NO2/c14(6)235/h56H,23H2,1H3
Substance Type: Organic
Physical State: Liquid
Key result
Conc. based on:
test mat.
Temp.:
25 °C
Remarks on result:
other: Completely miscible in water
Conclusions:
This study was conducted in compliance with OECD Guideline 105 and in accordance with the EPA GLP standards (40 CFR 160).
2-[(Hydroxymethyl)amino] ethanol was determined to be completely miscible with water at 25.0 ± 0.5°C.
Executive summary:

This study was conducted in compliance with OECD Guideline 105 and in accordance with the EPA GLP standards (40 CFR 160).

Preliminary solubility data indicated that the sample was miscible in two of the solvents to be tested: water and isopropanol. Therefore, the OECD method was modified for these solvents by equilibrating weight: weight (1:1) mixtures of sample and solvent at 25°C for 24 h, then analyzing the solutions to determine if the sample had been altered. Solubility was determined for technical grade Troysan 174 (Lot No. 89095340, 97.2% active ingredient) in water, octanol, and isopropanol. The study was monitored by supercritical fluid chromatography (SFC).

2-[(Hydroxymethyl)amino] ethanolwas determined to be completely miscible with water at 25.0 ± 0.5°C.

Description of key information

This study was conducted in compliance with OECD Guideline 105 and in accordance with the EPA GLP standards (40 CFR 160).

2-[(Hydroxymethyl)amino] ethanol was determined to be completely miscible with water at 25.0 ± 0.5°C.

Key value for chemical safety assessment

Water solubility:
1 000 000 mg/L
at the temperature of:
25 °C

Additional information

This study was conducted in compliance with OECD Guideline 105 and in accordance with the EPA GLP standards (40 CFR 160).

2-[(Hydroxymethyl)amino] ethanol was determined to be completely miscible with water at 25.0 ± 0.5°C.

WSKOW v1.42 was used to estimate the water solubility of2-[hydroxy(methyl)amino]ethanol. The estimated water solubility of 2-[hydroxy(methyl)amino]ethanol at 25 deg C was 1000000mg/l.

This value suggests that 2-[hydroxy(methyl)amino]ethanol is highly soluble in water.