Registration Dossier
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EC number: 251-974-0 | CAS number: 34375-28-5
Endpoint summary
Administrative data
Description of key information
Adsorption / desorption
The Soil Adsorption Coefficient i.e Koc value of 2-[hydroxy(methyl)amino]ethanol was estimated using EPI suite KOCWIN (v2.00) program as 1 L/kg (log Koc=0) by means of MCI method at 25 deg.C. This Koc value indicates that the substance 2-[hydroxy(methyl)amino]ethanol has a negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.
Additional information
Adsorption / desorption
Five results including different predicted data from validated models for adsorption (KOC) endpoint of target chemical 2-[hydroxy(methyl)amino]ethanol (Cas no. 34375-28-5) were summarized as follows:
First study from prediction by KOCWIN model (v2.00) of EPI suite which indicate the adsorption value of 2-[hydroxy(methyl)amino]ethanol was estimated as 1 L/kg(log Koc=0) by means of MCI method at 25 deg.C. This Koc value indicates that the substance 2-[hydroxy(methyl)amino]ethanol has a negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.
Above result is assist by ACD (Advanced Chemistry Development)/I-Lab; Algorithm Version: v5.0.0.184 using Adsorption Coefficient module (v12.1.0.50374) module; 2017 indicate the Koc value of test substance 2-[hydroxy(methyl)amino]ethanol was estimated using Adsorption Coefficient module (v12.1.0.50374) program as Koc 1 to 2.57 ( log Koc of max.value = 0.40) at pH range 1-14.. This Koc value indicates that the test substance has negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.
Result From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical) indicate the adsorption coefficient i.e KOC for test substance 2-[hydroxy(methyl)amino]ethanol was estimated to be 11.7 L/Kg.The predicted KOC result based on the 5 OECD principles. Thus based on the result it is concluded that the test substance 2-[hydroxy(methyl)amino]ethanol has high mobility in soil compartment.
And Scifinder database suggest the soil adsorption coefficient i.e Koc value of test substance 2-[hydroxy(methyl)amino]ethanol was estimated to be 1-2.52 (Log koc of max. value -0.40) at pH range 1-10 at temperature 25 deg.C. This Koc value at all range of pH condition indicates that the substance 2-[hydroxy(methyl)amino]ethanol has negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.
Last study from Chemspider - ACD/PhysChem Suite indicate the soil adsorption coefficient i.e Koc value of test substance 2-[hydroxy(methyl)amino]ethanol was estimated to be 1 (log koc: 0) at pH 5.5 and 1.76 (log koc: 0.24) at pH 7.4 and temp.25 deg.C. This Koc value at different pH indicates that the substance 2-[hydroxy(methyl)amino]ethanol has negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.
Thus all available studies for adsorption endpoint come to conclusion that the test substance 2-[hydroxy(methyl)amino]ethanol (Cas no. 34375-28-5) is expected to have high mobility in soil and sediment compartment.
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