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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation / corrosion
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from safety assessment reports

Data source

Reference
Reference Type:
secondary source
Title:
2-[(Hydroxymethyl)amino]ethanol: Reregistration Eligibility Decision (RED) and RED Fact Sheet
Author:
U. S. Environmental Protection Agency (EPA) Office of Pesticide Programs (OPP) Special Review and Reregistration Division (SRRD)
Year:
1993
Bibliographic source:
2-[(Hydroxymethyl)amino]ethanol: Reregistration Eligibility Decision (RED) and RED Fact Sheet, US EPA, 1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
An acute dermal irritation was conducted to assess the irritation potential of 2-[(Hydroxymethyl)amino]ethanol
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(hydroxymethylamino)ethanol
EC Number:
251-974-0
EC Name:
2-(hydroxymethylamino)ethanol
Cas Number:
34375-28-5
Molecular formula:
C3H9NO2
IUPAC Name:
2-[hydroxy(methyl)amino]ethanol
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): 2-(hydroxymethylamino)ethanol
- Molecular formula : C3H9NO2
- Molecular weight :91.11 g/mole
- Substance type: Organic
- Physical state:Liquid
- SMILES: OCCNCO
Specific details on test material used for the study:
Name of test material (as cited in study report): 2-[(Hydroxymethyl)amino] ethanol
Molecular formula: C3H9NO2
Molecular weight: 91.1091 g/mol
Smiles notation: CN(CCO)O
InChI: 1S/C3H9NO2/c14(6)235/h56H,23H2,1H3
Substance Type: Organic
Physical State: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data available

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
other: in an innocuous substrate
Controls:
not specified
Amount / concentration applied:
50% 2-[(Hydroxymethyl)amino]ethanol in an innocuous substrate
Duration of treatment / exposure:
no data available
Observation period:
no data available
Number of animals:
no data available
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
no irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
No irritation was observed when rabbits were dermally exposed to 2-[(Hydroxymethyl)amino]ethanol.
Hence, 2-[(Hydroxymethyl)amino]ethanol can be considered not irritating to rabbit skin.
Executive summary:

A skin irritation study was carried out in rabbits to assess the irritation potential of 2-[(Hydroxymethyl)amino]ethanol.50% 2-[(Hydroxymethyl)amino]ethanol in an innocuous substrate was applied to rabbit skin and observed for signs of irritation (duration not specified).

No irritation was observed when rabbits were exposed to 2-[(Hydroxymethyl)amino]ethanol.

Hence, 2-[(Hydroxymethyl)amino]ethanol can be considered not irritating to rabbit skin.