Registration Dossier
Registration Dossier
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EC number: 254-184-4 | CAS number: 38900-29-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The activated sludge respiration inhibition test does not need to be conducted as the substances in the lithium salts of dicarboxylic acids (C6 - C10) category are readily biodegradable at concentrations that may be expected in the influent of a sewage treatment plant.
Key value for chemical safety assessment
Additional information
The activated sludge respiration inhibition test does not need to be conducted as the substances in the lithium salts of dicarboxylic acids (C6 - C10) category are readily biodegradable at concentrations that may be expected in the influent of a sewage treatment plant. The substances would dissociate and biodegrade in the environment, resulting in carbon dioxide, water and lithium ions.
Biodegradation data are available for the organic components. In the biodegradation studies (Gerike and Fischer 1979), adipic acid was readily biodegradable at all concentrations tested (up to 50 mg/L DOC, equivalent to 109.6 mg/L dilithium adipate) and was inherently biodegradable at 400 mg/L DOC (equivalent to 877 mg/L dilithium adipate). Although no toxicity controls were undertaken in the studies, as adipic acid meets the criteria for ready biodegradability, it is not considered toxic to micro-organisms. This conclusion is read across to other members of the category.
The lithium ion is inorganic and therefore ready biodegradability is not relevant. Lithium has an EC50 of 52.29 mg/L and an EC10 of 22.95 mg/L for toxicity to aquatic micro-organisms (ECHA Dissemination Portal). This would equate to an EC10 of 260.8 mg/L for dilithium adipate, which is above the NOEC calculated from the adipic acid result, indicating that the lithium component would not drive any toxicity to micro-organisms.
This is supported by the ready biodegradability result for dilithium glutarate (C5 – see dissemination portal) which shows that the presence of the lithium ion is not expected to impact the degradation of the dilithium salts. Further testing on the ready biodegradability of dilithium sebacate is currently ongoing to confirm this conclusion.
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