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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vivo

Currently viewing:

Administrative data

Endpoint:
in vivo mammalian germ cell study: gene mutation
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer reviewed publication

Data source

Reference
Reference Type:
publication
Title:
Study of artificial flavouring substances for mutagenicity in the Salmonella/microsome, Basc and micronucleus tests
Author:
D. Wild, M.-T. King, E. Gocke and K. Eckhardt
Bibliographic source:
Fd Chem. Toxic. Vol. 21, No. 6, pp. 707-719, 1983

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Sex linked recessive lethal mutation assay (Wuergler et al., 1977)
Principles of method if other than guideline:
gene mutation in vivo is studied for the test compound 2 Phenylpropionaldehyde
GLP compliance:
not specified
Type of assay:
Drosophila SLRL assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydratropaldehyde
EC Number:
202-255-5
EC Name:
Hydratropaldehyde
Cas Number:
93-53-8
Molecular formula:
C9H10O
IUPAC Name:
hydratropaldehyde
Constituent 2
Reference substance name:
2 Phenylpropionaldehyde
IUPAC Name:
2 Phenylpropionaldehyde
Details on test material:
- Name of test material (as cited in study report): 2 Phenylpropionaldehyde
- Molecular formula (if other than submission substance): C9-H10-O
- Molecular weight (if other than submission substance): 134.177 g/mol
- Substance type: organic
- Physical state: No data available
Purity: No data available
- Impurities (identity and concentrations): No data available

Test animals

Species:
Drosophila melanogaster
Strain:
other: Berlin K (wild-type) and Basc strains
Sex:
male

Administration / exposure

Route of administration:
oral: feed
Vehicle:
Solutions or emulsions of test substances to be fed to the flies were prepared in 5% saccharose, with the addition of 2% ethanol and 2% Tween 80 for compounds that were poorly soluble in water.
Details on exposure:
No data available
Duration of treatment / exposure:
No data available
Frequency of treatment:
No data available
Post exposure period:
No data available
Doses / concentrations
Remarks:
Doses / Concentrations:
25mM
Basis:

No. of animals per sex per dose:
No data available
Control animals:
not specified
Positive control(s):
No data available

Examinations

Tissues and cell types examined:
No data available
Details of tissue and slide preparation:
No data available
Evaluation criteria:
SLRL mutation
Statistics:
Statistical significance determined by methods of Kastenbaum and Bowman (1970).

Results and discussion

Test results
Sex:
male
Genotoxicity:
negative
Toxicity:
not specified
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
The given test material 2 Phenylpropionaldehyde does not induce gene mutation in vivo in Drosophila melanogaster
Executive summary:

The Basc test on Drosophila was performed to study the gene mutation ability of2 Phenylpropionaldehyde.

 

Solutions or emulsions of test substances to be fed to the flies were prepared in 5% saccharose, with the addition of 2% ethanol and 2% Tween 80 for compounds that were poorly soluble in water.

 

The given test material2 Phenylpropionaldehydedoes not induce gene mutation in vivo in Drosophila melanogaster.