Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 453-570-1 | CAS number: 540734-22-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
OECD Guideline 301D, EU Method C.4-E, US EPA OPPTS 835.3110, GLP, key study, validity 2:
43% degradation after 28 days.
Not readily biodegradable.
Key value for chemical safety assessment
Additional information
One key study is available to assess the ready biodegradability of the substance in an aerobic aqueous medium. This study was performed according to OECD Guideline 301D, EU Method C.4 -E and US EPA OPPTS 835.3110.
The substance, at a concentration of 1.5 mg/l, was exposed to sewage treatment micro-organisms with culture medium in sealed culture vessels in the dark at 20 ± 1°C for 28 days.
The following test preparations were prepared and inoculated in 250-300 ml BOD bottles:
a) A control, in duplicate, consisting of inoculated culture medium.
b) The standard material (sodium benzoate), in duplicate, in inoculated culture medium to give a concentration of 3 mg/l.
c) The test material, in duplicate, in inoculated culture medium to give a concentration of 1.5 mg/l.
d) The test material (1.5 mg/l) plus the standard material (1.5 mg/l), in duplicate, in inoculated culture medium to act as a toxicity control.
The oxygen depletion of the inoculated control did not exceed 1.5 mg O2/l after 28 days, the residual oxygen concentration in the test bottles remained at 3.85 mg O2/l or greater in all test vessels and the difference between the extremes of replicate oxygen depletion values at the end of the test was less than 20% in all vessels thereby satisfying the validation criteria. Examination of the degradation curve for the toxicity control showed that the toxicity control attained in excess of 25% degradation by Day 14 of the study thereby confirming that the test material was not toxic to the sewage treatment micro-organisms used in the study. After 28 days the toxicity control had attained 52% degradation. The standard material, sodium benzoate, attained 86% degradation after 28 days thereby confirming the suitability of the test method and culture conditions.
The test material attained 43% degradation after 28 days and therefore cannot be considered to be readily biodegradable under the strict terms and conditions of OECD Guideline No 301D.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
