Registration Dossier
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EC number: 262-134-8 | CAS number: 60270-33-9
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2015
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification
Data source
Reference
- Reference Type:
- other: QSAR report
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- estimation of dermal absorption using IH SkinPerm based on physico-chemical properties
References:
ten Berge WF. (2009). A simple dermal absorption model: Derivation and application. Chemosphere 75, 1440-1445
Wilschut, A., ten Berge, W. F., Robinson, P. J., McKone, T. E. (1995) Estimating skin permeation. The Validation of five mathematical skin permeation models. Chemosphere 30, 1275-1296 http://home.planet.nl/~wtberge/qsarperm.html - GLP compliance:
- no
Test material
- Reference substance name:
- N-[3-(dimethylamino)propyl]docosanamide
- EC Number:
- 262-134-8
- EC Name:
- N-[3-(dimethylamino)propyl]docosanamide
- Cas Number:
- 60270-33-9
- Molecular formula:
- C27H56N2O
- IUPAC Name:
- N-[3-(dimethylamino)propyl]docosanamide
- Details on test material:
- - Chemical name: Behenamidopropyl dimethylamine
Constituent 1
- Radiolabelling:
- no
Administration / exposure
- Duration of exposure:
- 8 h
- Doses:
- 8997 mg
- No. of animals per group:
- not applicable
Results and discussion
Percutaneous absorptionopen allclose all
- Dose:
- 8997 mg
- Parameter:
- percentage
- Absorption:
- 0 %
- Remarks on result:
- other: 8 h
- Dose:
- 8997 mg
- Parameter:
- percentage
- Absorption:
- 0 %
- Remarks on result:
- other: 24 h
Any other information on results incl. tables
|
Dermal absorption after: |
|
8 h |
24 h |
|
Fraction absorbed [%] |
0.0 |
0.0 |
Amount absorbed [mg] |
0.11583 mg |
0.34752 mg |
Max. dermal absorption rate [mg/cm²/h] |
3.60E-06 |
3.60E-06 |
|
Chemical fate after: |
|
8 h |
24 h |
|
Evaporation [%] |
0 |
0 |
Deposition [%] |
93.8 |
91.7 |
Stratum corneum [%] |
6.2 |
8.3 |
Viable epidermis [%] |
0 |
0 |
Applicant's summary and conclusion
- Conclusions:
- The dermal absorption of DIMAPDO has been estimated to be 0% (calculation using the IH SkinPerm QSAR model, version v1.21).
- Executive summary:
The dermal absorption of DIMAPDO has been estimated by calculation using the IH SkinPerm (v1.21) model with the following parameters:
Scenario parameters:
Instantaneous deposition
Instantaneous deposition dose: 8997 mg
Affected skin area: 2000 cm²
Timing parameters:
Observation time:
8 h (start deposition 0 h, end time observation 8 h)
24 h (start deposition 0 h, end time observation 24 h)
The absorbed fractions have been estimated to be 0% after 8 and 24 h. The absorbed amounts have been estimated to be 0.12 and 0.35 mg after 8 and 24 h, respectively. The maximum dermal absorption rate has been calculated to be 3.60E-06 mg/cm²/h.
Due to missing information about the applicability of the calculation model in respect to the substance under investigation the results should be treated with care.
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