Registration Dossier
Registration Dossier
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EC number: 418-140-1 | CAS number: 5117-12-4 ACRYLOYLMORPHOLIN
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- other: not available
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to EG B.7 / OECD 407
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EG B.7 / OECD 407
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 4-(1-oxo-2-propenyl)-morpholine
- EC Number:
- 418-140-1
- EC Name:
- 4-(1-oxo-2-propenyl)-morpholine
- Cas Number:
- 5117-12-4
- Molecular formula:
- C7H11NO2
- IUPAC Name:
- 1-(morpholin-4-yl)prop-2-en-1-one
Constituent 1
Test animals
- Species:
- other: rat, Sprague-Dawley origin CD
Administration / exposure
- Route of administration:
- other: unspecified
- Vehicle:
- other: aqua dest
- Details on oral exposure:
- Method of administration: Magensonde (gavage)
- Duration of treatment / exposure:
- Test duration: 28 days
- Frequency of treatment:
- Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Male: 5 animals at 0 mg/kg bw/day
Male: 5 animals at 4.5 mg/kg bw/day
Male: 5 animals at 15 mg/kg bw/day
Male: 5 animals at 50 mg/kg bw/day
Female: 5 animals at 0 mg/kg bw/day
Female: 5 animals at 4.5 mg/kg bw/day
Female: 5 animals at 15 mg/kg bw/day
Female: 5 animals at 50 mg/kg bw/day
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
- Dose descriptor:
- NOEL
- Effect level:
- 15 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Classified as: Xn - harmful
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