Registration Dossier
Registration Dossier
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EC number: 418-140-1 | CAS number: 5117-12-4 ACRYLOYLMORPHOLIN
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: not specified
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- Physical form of substance: liquid
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Vehicle:
- other: none
- Details on inhalation exposure:
- 4h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- < 1 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- Male: .19 mg/L; Number of animals: 5; Number of deaths: 0
Male: .61 mg/L; Number of animals: 5; Number of deaths: 0
Male: .82 mg/L; Number of animals: 5; Number of deaths: 0
Male: 1.13 mg/L; Number of animals: 5; Number of deaths: 5
Male: 1.79 mg/L; Number of animals: 5; Number of deaths: 5
Male: 4.8 mg/L; Number of animals: 5; Number of deaths: 5
Female: .19 mg/L; Number of animals: 5; Number of deaths: 0
Female: .61 mg/L; Number of animals: 5; Number of deaths: 0
Female: .82 mg/L; Number of animals: 5; Number of deaths: 0
Female: 1.13 mg/L; Number of animals: 5; Number of deaths: 5
Female: 1.79 mg/L; Number of animals: 5; Number of deaths: 5
Female: 4.8 mg/L; Number of animals: 5; Number of deaths: 5 - Clinical signs:
- other: During the exposure most of the animals showed signs of an irritation e.g abnorm breating, closing or partial closing of the eyes and abnorm position. Directly after the exposure clinical signs as abnorm breathing, hypersensibility against touching and no
- Gross pathology:
- Macroscopic pathology: stowed lungs in all died animals. In many animals, which died during the study, the stomach was filled with liquid.
No change were observed in the animals surviving the treatment.
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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