Registration Dossier
Registration Dossier
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EC number: 418-140-1 | CAS number: 5117-12-4 ACRYLOYLMORPHOLIN
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to EG B.1 Teil B / OECD 401
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EG B.1 Teil B / OECD 401
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-(1-oxo-2-propenyl)-morpholine
- EC Number:
- 418-140-1
- EC Name:
- 4-(1-oxo-2-propenyl)-morpholine
- Cas Number:
- 5117-12-4
- Molecular formula:
- C7H11NO2
- IUPAC Name:
- 1-(morpholin-4-yl)prop-2-en-1-one
Constituent 1
Test animals
- Species:
- other: rat, Sprague-Dawley.
Administration / exposure
- Vehicle:
- other: none
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 588 mg/kg bw
- 95% CL:
- 524 - 701
- Remarks on result:
- other: Slope of the mortality curve: 11.3
- Mortality:
- Male: 400 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 500 mg/kg bw; Number of animals: 5; Number of deaths: 3
Male: 640 mg/kg bw; Number of animals: 5; Number of deaths: 4
Male: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 400 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 640 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 5 - Clinical signs:
- other: Shortly after application: piloerection, abnorm position, abnorm gait,lethargy, reduced breathing frequenz, pallor of extremities and increased salivation. Additionally ptosis in all rats after application of 500 mg/kg and more. 1000 kg/mg: clonic convuls
- Gross pathology:
- The autopsy of the rats which died during the study showed
in almost all rats a pallor of kidneys, spleen and/or liver.
The autopsy of the animals sacrificed at the end of the
study did not show deviations.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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