Registration Dossier
Registration Dossier
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EC number: 418-140-1 | CAS number: 5117-12-4 ACRYLOYLMORPHOLIN
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to Basierend auf der Vorschrift der Kommission für Produkt- sicherheit für den Verbraucher der Vereinigten Staaten von Amerika (Federal Regulation (CFR), par. 16, Absatz 15.41)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Basierend auf der Vorschrift der Kommission für Produkt- sicherheit für den Verbraucher der Vereinigten Staaten von Amerika (Federal Regulation (CFR), par. 16, Absatz 15.41)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-(1-oxo-2-propenyl)-morpholine
- EC Number:
- 418-140-1
- EC Name:
- 4-(1-oxo-2-propenyl)-morpholine
- Cas Number:
- 5117-12-4
- Molecular formula:
- C7H11NO2
- IUPAC Name:
- 1-(morpholin-4-yl)prop-2-en-1-one
Constituent 1
Test animals
- Species:
- other: rabbit,Weiße Neuseeländer
Test system
- Type of coverage:
- occlusive
- Vehicle:
- other: none
- Duration of treatment / exposure:
- 24h
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Score:
- 0.5
- Max. score:
- 1
- Remarks on result:
- other: Max. duration: 3 d; Max. value at end of observation period: 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: 0 d; Max. value at end of observation period: 0
- Irritant / corrosive response data:
- Reversibility of any observed effect: Changes fully reversible within 3 days
- Other effects:
- Results in the table refer to the intact skin.
The abraded sdkin was observed at the same animals at the
same time. The average scores for erythemae was 0.8 and for
edemae 0.
The max. values for erythema was 1 and for edema 0. The max.
duration was < 3 days.
The maximal values at the end of the study: 0.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
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