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EC number: 603-436-5 | CAS number: 13076-17-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-09-04 to 2009-12-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- adopted 27th July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): DD Lactide
- Batch no: 0809002497
- Purity 100 %
- Expiration date of the lot/batch: 2009-11-02
- Stability under storage conditions: stable
- test substance storage: at room temperature in the dark - Key result
- Water solubility:
- 16.3 g/L
- Temp.:
- 20.1 °C
- pH:
- 1.5
- Details on results:
- The results for the samples taken at 1, 2, 4, 24 and 48 hours showed, that concentration of the degradation product increased in time whereas concentration of DD-lactide remained stable over the first 24 hours. This indicates equilibrium between degradation and dissolution over this time period. At 48 hours no DD-lactide was detected. This was due to the fact that all DD-lactide had dissolved and degraded somewhere between 24 and 48 hours.
- Conclusions:
- DD-lactide degrades rapidly in water. Water solubility of this test substance at 20.1 ± 0.6 °C in the presence of excess undissolved DD-lactide, was determined to be 16.3 g/L. The pH of the aqueous sample after 24 hours of stirring was 1.5.
- Executive summary:
In this study the water solubility of DD-lactide was determined in accordance with OECD guideline 105. DD-lactide degrades rapidly in water. Water solubility of this test substance at 20.1 ± 0.6 °C in the presence of excess undissolved DD-lactide, was determined to be 16.3 g/L. The pH of the aqueous sample after 24 hours of stirring was 1.5.
Reference
| Table 1: Water solubility of the test substance | |||
| Stirring time | Analysed [C] | Mean [C] | pH |
| [h] | [g/L] | [g/L] 1 | |
| 1 | 16.7 | 16.3 | 2.1 |
| 2 | 17.3 | 2.0 | |
| 4 | 16.3 | 1.9 | |
| 6 | 15.3 | 1.8 | |
| 24 | 15.7 | 1.5 | |
| 48 | n.d. | 1.3 | |
1: mean of all concentrations over the first 24 hours
n.d.= not detected
Description of key information
The water solubility of DD-lactide was determined to be 16.3 g/L.
Key value for chemical safety assessment
- Water solubility:
- 16.3 g/L
- at the temperature of:
- 20 °C
Additional information
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