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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2009-09-04 to 2009-10-08
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Reason / purpose for cross-reference:
reference to same study
Principles of method if other than guideline:
In a guideline study with the aim to determine the particle size, a preliminary solubility test was conducted to choose a suitable dispersant.
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
- Name of test material (as cited in study report): DD Lactide
- Batch no: 0809002497
- Purity: 100%
- Expiration date of the lot/batch: 2009-09-23
- Stability under storage conditions: stable
- Storage: at room temperature in the dark
- Sample density: 1.31 g/cm³
Medium:
other: sunflower oil
Remarks on result:
other: insoluble, particle disintegration observed under microscope
Medium:
other: silicone oil
Remarks on result:
other: insoluble, good dispersion
Medium:
other: kerosene
Remarks on result:
other: insoluble, but poor dispersion
Medium:
toluene
Remarks on result:
other: soluble
Conclusions:
DD-lactide was found to be insoluble in kerosene, silicone oil and sunflower oils, but soluble in toluene.
Executive summary:

The solubility of the test item in organic solvents was assesed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. DD-lactide is insoluble in kerosene, silicone oil and vegetable oils, but soluble in toluene.

Description of key information

The solubility of the test item in organic solvents was assessed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. DD-lactide is insoluble in kerosene, silicone oil and sunflower oil, but soluble in toluene.

Key value for chemical safety assessment

Additional information