1,4-Dioxane-2,5-dione, 3,6-dimethyl-, (3R,6R)-

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

2009-09-04 to 2009-10-08

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Reason / purpose for cross-reference:

reference to same study

Principles of method if other than guideline:

In a guideline study with the aim to determine the particle size, a preliminary solubility test was conducted to choose a suitable dispersant.

GLP compliance:

yes (incl. QA statement)

Specific details on test material used for the study:

- Name of test material (as cited in study report): DD Lactide
- Batch no: 0809002497
- Purity: 100%
- Expiration date of the lot/batch: 2009-09-23
- Stability under storage conditions: stable
- Storage: at room temperature in the dark
- Sample density: 1.31 g/cm³

Medium:

other: sunflower oil

Remarks on result:

other: insoluble, particle disintegration observed under microscope

Medium:

other: silicone oil

Remarks on result:

other: insoluble, good dispersion

Medium:

other: kerosene

Remarks on result:

other: insoluble, but poor dispersion

Medium:

toluene

Remarks on result:

other: soluble

Conclusions:

DD-lactide was found to be insoluble in kerosene, silicone oil and sunflower oils, but soluble in toluene.

Executive summary:

The solubility of the test item in organic solvents was assesed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. DD-lactide is insoluble in kerosene, silicone oil and vegetable oils, but soluble in toluene.

Description of key information

The solubility of the test item in organic solvents was assessed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. DD-lactide is insoluble in kerosene, silicone oil and sunflower oil, but soluble in toluene.