Registration Dossier
Registration Dossier
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EC number: 249-854-8 | CAS number: 29797-40-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD Guideline or GLP defined
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG; L 251.
- Principles of method if other than guideline:
- In an acute dermal toxicity study in male and female Wistar rats the animals were treated with the test substance for 24 h on the shaved back and flank. The dose tested was 2000 mg/kg bw.
- GLP compliance:
- yes
- Test type:
- other: acute dermal toxicology study in rats
- Limit test:
- no
Test material
- Reference substance name:
- Dichloromethylbenzene
- EC Number:
- 249-854-8
- EC Name:
- Dichloromethylbenzene
- Cas Number:
- 29797-40-8
- Molecular formula:
- C7H6Cl2
- IUPAC Name:
- (dichloromethyl)benzene
- Details on test material:
- 99.02 % Dichlortoluol-Isomer-Mixture:
<0.05 % o-Chlortoluol,
<0.05 % m+p-Chlortoluol,
6.6 % 2.6-Dichlortoluol,
25.9 % 2.4-Dichlortoluol,
44.9 % 2.5-Dichlortoluol,
9.2 % 2.3-Dichlortoluol,
12.6 % 3.4-Dichlortoluol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw.
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD 50 was >2000 mg/kg bw.
- Executive summary:
In an acute dermal toxicity study in male and female Wistar rats the animals were treated with the test substance for 24 h on the shaved back and flank. The dose tested was 2000 mg/kg bw. After 24 h the occlusive coverage was removed and the leftovers of test substance were washed with lukewarm water. Up to 30 minutes after application the female and male animals made sounds. After one hour all animals were symptom-free. No local skin changes were observed. During the 14 day observation-period no animal died. The LD 50 therefore was >2000 mg/kg bw.
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