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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline defined.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.1 (Acute Toxicity (Oral))
Version / remarks:
Cited as Directive 84/449/EEC, B.1
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dichloromethylbenzene
EC Number:
249-854-8
EC Name:
Dichloromethylbenzene
Cas Number:
29797-40-8
Molecular formula:
C7H6Cl2
IUPAC Name:
(dichloromethyl)benzene
Details on test material:
Test substance: as prescribed by 1.1 - 1.4;
Mixture of :
98.7% Dichlortouole, <0.1% Chlortoluole, 1.1% Trichlortoluole

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Polyethyleneglycol 400
Doses:
1000, 2500, 2650 (only female rats), 3000, 3550, 5000 mg/kg bw.
No. of animals per sex per dose:
1000 mg/kg= 5 animals/sex,
2500 mg/kg= 5 animals/sex,
2650 mg/kg= 5 female rats,
3000 mg/kg bw= 10 male, 15 female animals,
3550 mg/kg bw= 5 animals/sex,
5000 mg/kg bw=5 animals/sex.
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
3 179 mg/kg bw
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
2 344 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD 50 for male rats was 3179 mg/kg and the LD 50 for female rats was 2344 mg/kg bw.
Executive summary:

In an acute oral toxicity study in male and female Wistar rats, the animals received the test substance via gavage. Following doses were tested: 1000, 2500, 2650 (only female rats), 3000, 3550, 5000 mg/kg bw. The LD 50 for male rats was 3179 mg/kg and the LD 50 for female rats was 2344 mg/kg bw.