Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: case report
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Case reports.

Data source

Reference
Reference Type:
publication
Title:
Cross reactions between methyl methacrylate monomer and acrylic monomers presently used in acrylic nail preparations.
Author:
Fisher AA
Year:
1980
Bibliographic source:
Contact Derm. 6: 345-347

Materials and methods

Type of study / information:
other: Skin sensitization, case reports:
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methacrylic acid
EC Number:
201-204-4
EC Name:
Methacrylic acid
Cas Number:
79-41-4
Molecular formula:
C4H6O2
IUPAC Name:
methacrylic acid
Test material form:
liquid

Method

Details on study design:
Patch testing with 1 % methacrylic acid in petrolatum of 2 patients, who previously had had allergic reactions to  methacrylic methacrylate monomer

Results and discussion

Results:
Patch testing of 2 patients, who previously had had allergic reactions to  methacrylic methacrylate monomer, gave a negative response when tested  with 1 % methacrylic acid in petrolatum.

Applicant's summary and conclusion