Registration Dossier
Registration Dossier
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EC number: 201-204-4 | CAS number: 79-41-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Screening test; 2 animals per dose group, summarized description of the method used and the results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
- Report date:
- 1956
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: dermal toxicity screening
- Principles of method if other than guideline:
- Screen for dermal toxicity/absorption, 2 animals per group
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Methacrylic acid
- EC Number:
- 201-204-4
- EC Name:
- Methacrylic acid
- Cas Number:
- 79-41-4
- Molecular formula:
- C4H6O2
- IUPAC Name:
- methacrylic acid
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Purity not specified, typically >= 98 %
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Details on dermal exposure:
- Substance prepared 50% in water
- Doses:
- 0.5, 1.0 and 2.0 g/kg.
- No. of animals per sex per dose:
- 2/group
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- >= 500 - <= 1 000 mg/kg bw
- Mortality:
- Dose (mg/kg) mortality
500 0/2
1000 2/2
2000 2/2 - Clinical signs:
- other: At 500 mg/kg (50 % solution in water) there was slight weight loss and the skin was severely burned. At 1000 mg/kg the animals died overnight.
- Other findings:
- Toxicity due to dermal corrosion.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- In a valid screening study, the acute dermal LD50 in rabbits of MAA was 500-1000 mg/kg bw.
- Executive summary:
In a valid screening study, the acute dermal LD50 in rabbits of MAA was 500-1000 mg/kg bw.
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