Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption
Type of information:
other: EU Guidance Document
Reliability:
other: not applicable
Data waiving:
other justification
Justification for data waiving:
other:

Data source

Reference
Reference Type:
other: Guidance Document
Title:
Unnamed
Year:
2004
Report date:
2004

Materials and methods

Results and discussion

Percutaneous absorption
Parameter:
percentage
Absorption:
10 %
Remarks on result:
other:

Applicant's summary and conclusion

Conclusions:
As a first conservative approach 1% dermal absorption should be used in exposure assessments.
Executive summary:

Dermal absorption is considered to be low, but no study is known to exist. A conservative approach proposed by the European Commission (Guidance Document on Dermal Absorption, 2004) is to assume a dermal absorption rate of 10% is in case the molecular weight is >500 and the log Pow is smaller than -1 or higher than 4, and otherwise to assume 100% absorption.

In the case of formate salts the dermal absorption is considered to be less than 10% because the salt is highly water soluble, and fully ionized in aqueous solution. It is known, and also stated in the Guidance Document, that highly ionized substances do not penetrate very much.

The Guidance is available underhttp://ec.europa.eu/food/plant/protection/evaluation/guidance/wrkdoc20_rev_en.pdf

 

As a first approach, a dermal absorption of 1% is therefore assumed and used in exposure assessments.