Calcium diformate

Partition coefficient

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

partition coefficient

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

27/03/2002

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

It is considered appropriate to address the partition coefficient data requirement for calcium formate by read-across to an available study on formic acid.

Calcium formate is a salt of formic acid is a member of the Formates Category. Calcium formate will immediately dissociate in water to formic acid and counter ions. It is therefore expected that the partition coefficient of calcium formate and formic acid will be similar.

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient)

Version / remarks:

Cited as Directive 92/69/EEC, A.8

GLP compliance:

yes

Type of method:

flask method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

-2.1

Temp.:

23 °C

pH:

7

Key result

Type:

log Pow

Partition coefficient:

-1.9

Temp.:

23 °C

pH:

5

Key result

Type:

log Pow

Partition coefficient:

-2.3

Temp.:

23 °C

pH:

9

log Kow at pH 5 and T (23°C +/- 1°C) = -1.9
log Kow at pH 7 and T (23°C +/- 1°C) = -2.1
log Kow at pH 9 and T (23°C +/- 1°C) = -2.3

Conclusions:

The partition coefficient of a supporting substance, formic acid, was measured to be -1.9, -2.1 and -2.3 at pH 5, 7, and 9, respectively, at 23±1°C, in a study run using EC method A.8.

Executive summary:

The partition coefficient of a supporting substance, formic acid, was measured to be -1.9, -2.1 and -2.3 at pH 5, 7, and 9, respectively, at 23±1°C, in a study run using EC method A.8.

Reference 2

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

Feb 02, 2010

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

GLP compliance:

not specified

Type of method:

shake-flask method to: flask method

Partition coefficient type:

octanol-water

Analytical method:

other: atomic emission spectroscopy (in duplicate)

Type:

log Pow

Partition coefficient:

< -2.6

Temp.:

20 °C

pH:

6.4

Flask	pH in water phase	water phase 1	water phase 2	n-octanol phase 1	n-octanol phase 2	log Pow
1:1	6.3	1.268 mg/mL	1.264 mg/mL	0.003 mg/mL	0.003 mg/mL	-2.62
1:2	6.5	0.752 mg/mL	0.765 mg/mL	0.003 mg/mL	0.003 mg/mL	-2.41
2:1	6.6	1.225 mg/mL	1.284 mg/mL	0.003 mg/mL	0.003 mg/mL	-2.63

Conclusions:

The log partition coefficient of the calcium formate was measured to be between -2.6 and -2.4 in a study run to OECD 107.

Executive summary:

The log partition coefficient of the calcium formate was measured to be between -2.6 and -2.4 in a study run to OECD 107.

Description of key information

log Kow: <-2.3 at pH 7/ 23 °C (EU method A.8; BASF, 2002)

Key value for chemical safety assessment

Log Kow (Log Pow):

-2.3

at the temperature of:

20 °C