Acetophenone

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: ; study acceptable as supporting information

Data source

Reference

Reference Type:

publication

Title:

Toxicité et pouvoir hypnotique de l'acetophenone et des thienylketones (French). (Toxicity and hypnotic potential of acetophenone and thienylketones)

Author:

Quevauviller A

Year:

1946

Bibliographic source:

C R Soc Biol Année 1946: 367-369

Materials and methods

Principles of method if other than guideline:

Acetophenone was applied by intrapertioneal injection and clinical symptoms and mortality was investigated

Test material

Test material information

Constituent 1

Reference substance name:

Acetophenone

EC Number:

202-708-7

EC Name:

Acetophenone

Cas Number:

98-86-2

Molecular formula:

C8H8O

IUPAC Name:

1-phenylethanone

Test animals

Species:

mouse

Strain:

not specified

Sex:

male

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

olive oil

Doses:

range from < 400 mg/kg bw to > 700 mg/kg bw

No. of animals per sex per dose:

7-8

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LD50

Effect level:

1 070 mg/kg bw

Effect levels 2

Sex:

male

Dose descriptor:

LD100

Effect level:

1 600 mg/kg bw

Any other information on results incl. tables

Clinical symptoms:

400 - 500 mg/kg: within 5 min staggering gait, within 13 min paraparesis, within 20 min tetraparesis

700 mg/kg: maximum tolerable dose

> 700 mg/kg: death occurring more or less rapid by respiratory depression

Applicant's summary and conclusion

Conclusions:

For intraperitoneal application the maximal tolerable dose was found to be 700 mg/kg bw in mice. At higher concentrations death occured by respiratory depression with a LD50 of 1,070 mg/kg and a LD100 of 1,600 mg/kg. The target of the acute toxic action of acetophenone was the nervous system.

Executive summary:

Acetophenone was applied by intraperitoneal injection (vehicle olive oil) to mice and clinical symptoms and mortality was investigated. In the dose range of 400-500 mg/kg depression of the nervous system occurred within 5 min indicated by symptoms as staggering gait followed by paraparesis and tetraparesis. The maximal tolerable dose was found to be 700 mg/kg bw. At higher concentrations death occured by respiratory depression with a LD₅₀ of 1,070 mg/kg and a LD₁₀₀ of 1,600 mg/kg.