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REACH

Acetophenone

EC number: 202-708-7 | CAS number: 98-86-2

Life Cycle description
Uses advised against

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

Several valid studies dealing with the acute toxicity of acetophenone towards fish are available. In one study the acute toxicity to fish was investigated under flow-through conditions and with analytical monitoring. The study was conducted comparable to OECD guideline 203 'Fish, acute toxicity'. Acetophenone shows a low toxicity towards Pimephales promelas: 96 h LC50 and EC50=162 mg/L measured.
Another study was conducted according to the national standard method US EPA (1975) with analytical monitoring. Based on the results, acetophenone shows a low acute toxicity towards Pimephales promelas (96 h LC50=161 -162 mg/L).
A further study was conducted according to 'Standard practice for conducting acute toxicity tests with fishes, macroinvertebraten, and amphibians (ASTM, 1980) . Test substance concentration were measured daily via GC/FID, GC/ECD and/or HPLC. Based on the results, acetophenone can be regarded as substance with a low acute toxicity towards Pimephales promelas (96 h LC50=236 mg/L). A further study was conducted comparable to US EPA (1975) The concentrations  were tested under static conditions and not measured but the test vessels were covered with glass to reduce evaporation.  Based on the results, acetophenone shows a low acute toxicity towards Pimephales promelas  (96 h LC50=155 mg/L nominal).

Key value for chemical safety assessment

Fresh water fish

Effect concentration:: 162 mg/L

Additional information

Valid and reliable results from studies conducted comparable to OECD Guideline 203 and according to national standard methods are available. 
The study of Brooke et al. (1984) was selected as key study due to the test design (flow-through conditions, analytical monitoring of test 
substance concentration) and the comprehensive documentation although Mattson et al. (1976) found the lowest 96 h LC50 due to the 
drawbacks of this study (static conditions, no analytical monitoring of test substance concentration, limited documentation).

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