Registration Dossier
Registration Dossier
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EC number: 204-528-4 | CAS number: 122-20-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 08. Mar 1966 - 21. Mar 1966
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
- Principles of method if other than guideline:
- other: BASF-Test
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,1',1''-nitrilotripropan-2-ol
- EC Number:
- 204-528-4
- EC Name:
- 1,1',1''-nitrilotripropan-2-ol
- Cas Number:
- 122-20-3
- Molecular formula:
- C9H21NO3
- IUPAC Name:
- 1-[bis(2-hydroxypropyl)amino]propan-2-ol
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Analytical purity: ca. 92-95 %
- Impurities (identity and concentrations): ca. 3-6 % Diisopropanolamine; < 1 % Monoisopropanolamine
Test animals
- Species:
- mouse
- Strain:
- other: Kisslegg-mice
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 200, 400, 800, 1000, 1250, 1600 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 400 mg/kg bw
- Mortality:
- 1600 mg/kg: all animals died within the first 24 h.
1250 mg/kg: 1 female died within 24 h. - Clinical signs:
- 1600 mg/kg:
15 min post application: abdominal position, fluffed fur, intermittent respiration.
25 min post application: slight tremulous convulsions, abdominal position, accelerated respiration, mouth discharge, partly dyspnoea.
1250 and 1000 mg/kg:
15 min post application: staggering, accelerated respiration, abdominal position, flattened ears.
1 and 2 days post application: heavy ruffled fur, accelerated respiration, high stepping tremulous gait.
3 and 4 days post application: accelerated respiration, high stepping tremulous gait.
800 and 400 mg/kg:
10 min post application: high stepping, hoppling gait, accelerated respiration, gaunted sides, flattened ears, animals don´t continue in abominal position.
5 h and 1 day post application: abdominal position, heavy fluffed fur, gaunted sides, very calm attitude.
200 mg/kg: 5 h post application fluffed fur and accelerated respiration. - Gross pathology:
- 1250 mg/kg: 6x agglutination of intestinal loops.
800 mg/kg: 2x agglutination of intestinal loops.
Any other information on results incl. tables
Mortality:
| Dose (mg/kg) | Conc. (%) | 1 h | 24 h | 48 h | 7 days | 14 days |
| 1600 | 20 | 0/10 | 10/10 | 10/10 | 10/10 | - |
| 1250 | 8 | 0/10 | 1/10 | 1/10 | 1/10 | - |
| 1000 | 8 | 0/10 | 0/10 | 0/10 | 0/10 | - |
| 800 | 8 | 0/10 | 0/10 | 0/10 | 0/10 | - |
| 400 | 8 | 0/10 | 0/10 | 0/10 | 0/10 | - |
| 200 | 2 | 0/10 | 0/10 | 0/10 | 0/10 | - |
Applicant's summary and conclusion
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