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Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011-08-04 to 2011-08-05
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
April 2004
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
May 2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
Version / remarks:
August 1996
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
3.17
Temp.:
25 °C
pH:
6.1
Type:
Pow
Partition coefficient:
1 466
Temp.:
25 °C
pH:
6.1
Details on results:
The partition coefficient Pow was determined based on a calibration curves using six reference items. The capacity factors k were calculated from the retention times of the reference substances and the dead time. The log k data of the reference substances were plotted against their log Pow values. From this correlation graph of the reference items, the partition coefficient of the test item was interpolated.
Conclusions:
The log Pow of TBPPI was determined to be 3.17 +/- 0.005 (with 95 % confidence interval). The estimated Pow was 1466 +/- 16 (with 95 % confidence interval).
Executive summary:

The partition coefficient of TBPPI was determined according to EU method A.8, OECD Guideline 117, and EPA OPPTS 830.7570 guideline. Using the the HPLC method the partition coefficient Pow of TBPPI was determined to be 3.17 +/- 0.005 (with 95 % confidence interval). The estimated Pow was 1466 +/- 16 (with 95 % confidence interval) at 25 °C.

Description of key information

The log Pow of TBPPI was determined to be 3.17 +/- 0.005 (with 95 % confidence interval). The estimated Pow was 1466 +/- 16 (with 95 % confidence interval).

Key value for chemical safety assessment

Log Kow (Log Pow):
3.17
at the temperature of:
25 °C

Additional information

The partition coefficient of TBPPI was determined according to EU method A.8, OECD Guideline 117, and EPA OPPTS 830.7570 guideline. Using the HPLC method the partition coefficient Pow of TBPPI was determined to be 3.17 +/- 0.005 (with 95 % confidence interval). The estimated Pow was 1466 +/- 16 (with 95 % confidence interval) at 25 °C.