2-methylpentane-2,4-diol

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific principles, acceptable for assessment but without detailed documentations

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Further studies on sensory response to certain industrial solvent vapors

Author:

Silverman L, Schulte HF, First MW

Year:

1946

Bibliographic source:

J Ind Hyg Toxicol., 28: 262-266

Reference 2

Reference Type:

publication

Title:

Sensory Response to Certain Industrial Solvent Vapor

Author:

Nelson KW, Ege JF, Ross M, Woodman LE and Silverman L

Year:

1943

Bibliographic source:

J Ind Hyg Toxicol., 25, 282-285

Materials and methods

Endpoint addressed:

eye irritation

Principles of method if other than guideline:

Exposure of 12 male and 12 female test persons to hexylene glycol vapour in a concentration of 50 ppm (approximates the saturation concentration at 25°C) for 15 minutes.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methylpentane-2,4-diol

EC Number:

203-489-0

EC Name:

2-methylpentane-2,4-diol

Cas Number:

107-41-5

Molecular formula:

C6H14O2

IUPAC Name:

2-methylpentane-2,4-diol

Details on test material:

Technical grade solvent supplied by the Shell Development Company, Emeryville, California

Method

Ethical approval:

not specified

Exposure assessment:

not specified

Details on exposure:

The experimental procedure was similar to that described by Nelson et al., (1943). An average number of twelve subjects of both sexes were used for each solvent exposure. The procedure used previously was modified as follows: 1) The time of exposure was increased to fifteen minutes. This period permitted more accurate observation of olfactory fatigue and a better appraisal of increasing or decreasing irritation of mucous membranes. 2) During the 15 minute exposure period, motion pictures were shown te occupy the subjects' attention and divert their thoughts from the atmospheric contamination to which they were expose.

Results and discussion

Results:

A maximum allowable limit has not been determined previously A majority of subjects found HG irritating to the eyes at 50 p.p.m., which is approximately saturation concentration at room temperature (25° C.). HG a weak odor and, except for slight irritation of the eyes, there appears to be little objection to it at the highest concentrations possible as a vapor at room temperature.

Any other information on results incl. tables

SENSORY LIMITS OBTAINED ON SOLVENT VAPORS

Solvent	Highest concentration which majority of subjects estimated satisfactory for 8-hour exposure ppm	Concentration of vapour which irritated majority of subjects			Suggested maximum allowable concentrations ppm
		Eyes ppm	Nose ppm	Throat ppm
Hexylene glycol	50	50	>50	>50	None

Applicant's summary and conclusion

Executive summary:

Exposure of 12 male and 12 female test persons to hexylene glycol vapour in a concentration of 50 ppm (approximates the saturation concentration at 25°C) for 15 minutes caused eye irritation in most of the persons but no irritation of the nose or throat. The maximum tolerable concentration was considered to be 50 ppm.