Registration Dossier
Registration Dossier
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EC number: 203-489-0 | CAS number: 107-41-5
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No effect of hexylene glycol was seen on algae growth rate inhibition up to the highest tested concentration (429 mg/L). Therefore, a NOEC of 429 mg/L is considered for algae.
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 429 mg/L
Additional information
The potential of hexylene glycol to inhibit the growth of algae has been assessed in a study conducted in accordance with the OECD Guidelines for the Testing of Chemicals No. 201 and in compliance with GLP (Thiébaud and Chedaille, 1999). The study was performed with Selenastrum capricornutum (i.e.,Pseudokirchnerella subcapitata) using a freshwater, static test system. An initial biomass concentration of 1000 cells/mL was exposed to hexylene glycol at nominal concentrations of 60, 102, 173, 294, or 500 mg/L for 72 hours in triplicate. Based on measured concentrations, the 72-hour NOEC for hexylene glycol was determined to be 429 mg/L, the highest concentration tested. The 72-hour EC50 values for both biomass and growth rate, as well as the 72-hour EC10 values for these endpoints, were determined to be greater than 429 mg/L. Furthermore, microscopic observation confirmed that the algae appeared normal at the end of the test in comparison to the control, and the validity criteria of the test was fulfilled. Therefore, hexylene glycol did not exhibit growth inhibiting properties when tested in algae.
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