Registration Dossier
Registration Dossier
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EC number: 225-863-2 | CAS number: 5124-30-1
Stability in organic solvents and identity of relevant degradation products
Administrative data
Link to relevant study record(s)
- Endpoint:
- stability in organic solvents and identity of relevant degradation products
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
- Test substance stable:
- no
- Transformation products:
- yes
- Executive summary:
Isocyanates form urethanes in alcohol (Beyer, 2004)
- Endpoint:
- stability in organic solvents and identity of relevant degradation products
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: "in house" method "Determination of the NCO-content by capillary GC-chromatography".
- GLP compliance:
- yes
- Test substance stable:
- yes
- Transformation products:
- not measured
- Executive summary:
The concentration of the test substance in the acetonitrile solution without addition of water was stable over at least 2 hours at room temperature (Bayer AG, 1999).
Referenceopen allclose all
In alcohol, urethanes were formed by isocyanates.
The concentration of the test substance in the acetonitrile solution without addition of water was stable over the measurement time (at least 6 hours) at room temperature. |
Description of key information
In protic solvents like alcohols, isocyanates react rapidly. Stablility is expected with non-protic solvents like toluene, acetone, dioxane etc. Isocyanates form urethanes in alcohol. The concentration of 4,4’-methylenedicyclohexyl diisocyanate in an acetonitrile solution without addition of water was stable over at least 6 hours at room temperature.
Additional information
Reference:
Bayer AG, 1999
Guideline:
"in house" method "Determination of the NCO-content by capillary GC-chromatography"
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